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Published TCIMAIL newest issue No.197
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CAS RN: 236395-14-5 | Product Number: E1046
Eslicarbazepine Acetate
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Purity: >98.0%(HPLC)(N)
Synonyms:
- BIA 2-093
- (S)-(-)-10-Acetoxy-10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 200MG |
€111.00
|
2 | 1 |
|
| 1G |
€381.00
|
2 | 11 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | E1046 |
| Purity / Analysis Method | >98.0%(HPLC)(N) |
| Molecular Formula / Molecular Weight | C__1__7H__1__6N__2O__3 = 296.33 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 236395-14-5 |
| Reaxys Registry Number | 8336447 |
| PubChem Substance ID | 253662249 |
| MDL Number | MFCD06798333 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(with Total Nitrogen) | min. 98.0 % |
| Melting point | 185.0 to 189.0 °C |
| Specific rotation [a]20/D | -20.0 to -24.0 deg(C=1, Pyridine) |
Properties (reference)
| Melting Point | 187 °C |
| Specific Rotation | -22° (C=1,Pyridine) |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H336 : May cause drowsiness or dizziness. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P261 : Avoid breathing dust. P271 : Use only outdoors or in a well-ventilated area. P304 + P340 + P312 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER/doctor if you feel unwell. P403 + P233 : Store in a well-ventilated place. Keep container tightly closed. P405 : Store locked up. |
Related Laws:
Transport Information:
| HS Number | 2933998090 |
Application
Romifidine: a potent and selective α2-adrenoceptor agonist
Eslicarbazepine acetate (BIA 2-093 or ESL) is a central nervous system (CNS)-active compound with anticonvulsant activity. BIA 2-093 has voltage-gated sodium channel (VGSC) blocking property. BIA 2-093 is metabolized to eslicarbazepine (S-licarbazepine), an active metabolite of oxcarbazepine [O0363], which is responsible for pharmacological activity. BIA 2-093 is used as a third generation antiepileptic drugs (AEDs), and is often used in combination with the other AEDs. (The product is for research purpose only.)
References
- Anticonvulsant and sodium channel-blocking properties of novel 10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide derivatives
- Metabolism of two new antiepileptic drugs and their principal metabolites S(+)- and R(-)-10,11-dihydro-10-hydroxy carbamazepine
- Enantioselective HPLC-UV method for determination of eslicarbazepine acetate (BIA 2-093) and its metabolites in human plasma
- Eslicarbazepine acetate (BIA 2-093) (a review)
- Drug interactions involving the new second- and third-generation antiepileptic drugs (a review)
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