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Published TCIMAIL newest issue No.197
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CAS RN: 33419-42-0 | Product Number: E0675
Etoposide
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Purity: >98.0%(HPLC)
Synonyms:
- 4'-Demethylepipodophyllotoxin 9-(4,6-O-Ethylidene-β-D-glucopyranoside)
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 100MG |
€61.00
|
5 | 5 |
|
| 1G |
€384.00
|
2 | 24 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | E0675 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__9H__3__2O__1__3 = 588.56 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Condition to Avoid | Light Sensitive |
| Packaging and Container | 100MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 33419-42-0 |
| Reaxys Registry Number | 365969 |
| PubChem Substance ID | 87558799 |
| Merck Index (14) | 3886 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Water | max. 7.0 % |
Properties (reference)
| Melting Point | 251 °C |
| Solubility (slightly sol. in) | Ethanol |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H302 : Harmful if swallowed. H360 : May damage fertility or the unborn child. H362 : May cause harm to breast-fed children. H371 : May cause damage to organs. H372 : Causes damage to organs through prolonged or repeated exposure. H340 : May cause genetic defects. H350 : May cause cancer. |
| Precautionary Statements | P263 : Avoid contact during pregnancy and while nursing. P260 : Do not breathe dust. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. P308 + P311 : IF exposed or concerned: Call a POISON CENTER/doctor. |
Related Laws:
| EC Number | 251-509-1 |
| RTECS# | KC0190000 |
Transport Information:
| HS Number | 2938909090 |
Application
Adeno-associated virus vector transduction enhancer
Etoposide exhibits enhancement of adeno-associated virus transduction.1)
References
- 1) Identification and validation of small molecules that enhance recombinant adeno-associated virus transduction following high-throughput screens
Application
Etoposide: A Topoisomerase-II Inhibitor
Etoposide (VP 16) is a semisynthetic antitumor alkaloid which is synthesized form podophyllotoxin [P1771] , a toxin found in the American Mayapple. Etoposide interferes with DNA synthesis by inhibiting the enzyme topoisomerase-II. In order to prevent and correct of topological problems caused by the DNA double helix, topoisomerase-II catalyzes the relaxation of negatively supercoiled DNA, the knotting and unknotting DNA and the linking complementary rings of single-stranded DNA into double-stranded rings. Then the inhibition action leads to cell cycle arrest at G2/M, apoptosis or cell death. Bacterial type II topoisomerases (DNA gyrase and Topoisomerase-IV) are the targets of quinolone antibiotics.
References
- Etoposide: four decades of development of a topoisomerase II inhibitor(a review)
- Etoposide, topoisomerase II and cancer(a review)
- Plants as a source of anti-cancer agents(a review)
- DNA Topoisomerases and Their Poisoning by Anticancer and Antibacterial Drugs(a review)
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