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Published TCIMAIL newest issue No.197
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CAS RN: 56-75-7 | Product Number: C2255
Chloramphenicol
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Purity: >98.0%(T)(HPLC)
Synonyms:
- D-(-)-threo-2-Dichloroacetamido-1-(4-nitrophenyl)-1,3-propanediol
- 2,2-Dichloro-N-[(1R,2R)-1,3-dihydroxy-1-(4-nitrophenyl)-2-propyl]acetamide
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 25G |
€35.00
|
20 | ≥100 |
|
| 250G |
€236.00
|
3 | ≥80 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | C2255 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__1H__1__2Cl__2N__2O__5 = 323.13 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Condition to Avoid | Light Sensitive |
| CAS RN | 56-75-7 |
| Reaxys Registry Number | 2225532 |
| PubChem Substance ID | 87560304 |
| Merck Index (14) | 2077 |
| MDL Number | MFCD00078159 |
Specifications
| Appearance | White to Orange to Green powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Argentometric Titration) | min. 98.0 % |
| Melting point | 149.0 to 153.0 °C |
| Specific rotation [a]20/D | +17.0 to +21.0 deg(C=5, EtOH) |
Properties (reference)
| Melting Point | 151 °C |
| Specific Rotation | 20° (C=5,EtOH) |
| Solubility (soluble in) | Ether, Chloroform |
| Solubility (insoluble in) | Benzene |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H361 : Suspected of damaging fertility or the unborn child. H372 : Causes damage to organs through prolonged or repeated exposure. H373 : May cause damage to organs through prolonged or repeated exposure. H340 : May cause genetic defects. H350 : May cause cancer. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P260 : Do not breathe dust. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. |
Related Laws:
| EC Number | 200-287-4 |
| RTECS# | AB6825000 |
Transport Information:
| HS Number | 2941400000 |
Application
RNA aptamer research
Reference
- RNA aptamers to the peptidyl transferase inhibitor chloramphenicol
Application
Chloramphenicol: A Broad Spectrum Antibiotic and a Selective Reagent Genetically Engineered Cells
Chloramphenicol was originally isolated from the soil bacterium Streptomyces venezuelae in 1947. Chloramphenicol and a congener thiamphenicol [T2802] can now be made by chemical synthesis. Chloramphenicol has a highly stable which can be stored for prolonged times at room temperature. It has a broad spectrum of antibiotic activity including Staphylococcus aureus, Streptococcus pneumoniae, and Escherichia coli, while it is not effective against Pseudomonas aeruginosa. Chloramphenicol inhibits protein synthesis in susceptible organisms by binding to specific nucleotides in 23S rRNA within the 50S subunit of a bacterial ribosome. However, chloramphenicol causes side effects including bone marrow suppression and aplastic anemia. Chloramphenicol is used in molecular biology as a selective reagent most commonly to isolate bacteria coupled to a gene coding for chloramphenicol resistance, which is one of the most frequently used selection markers for obtaining transgenic cells.
References
- Chloramphenicol: Relation of Structure to Activity and Toxicity (a review)
- Structural basis for the interaction of antibiotics with the peptidyl transferase center in eubacteria
- Molecular basis of bacterial resistance to chloramphenicol and florfenicol (a review)
- High-copy-number and low-copy-number plasmid vectors for lacZ α-complementation and chloramphenicol- or kanamycin-resistance selection
- A comparative study on the inhibitory actions of chloramphenicol, thiamphenicol and some fluorinated derivatives
- Identification of 113 conserved essential genes using a high-throughput gene disruption system in Streptococcus pneumoniae
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