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Published TCIMAIL newest issue No.197
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CAS RN: 316-41-6 | Product Number: B0451
Berberine Sulfate
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Purity: >98.0%(T)(HPLC)
Synonyms:
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 5G |
37,00 €
|
2 | 5 |
|
| 25G |
114,00 €
|
1 | 11 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
Supplemental Product Information:
Previously this product had been labeled as a hydrate form both in product name and molecular formula. The hydrate form had no exclusive CAS RN and used to share the same CAS RN as the anhydrous form.
To avoid any misleading information and since moisture in product is considered as an impurity, we have decided to remove the term 'Hydrate' from product name and 'xH2O' from the molecular formula for such products.
Please use it at ease since there is no difference in product quality, even if you see the previous indications on a part of label.
| Product Number | B0451 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__4__0H__3__6N__2O__1__2S = 768.79 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 316-41-6 |
| Reaxys Registry Number | 3877732 |
| PubChem Substance ID | 87563488 |
| SDBS (AIST Spectral DB) | 5030 |
| Merck Index (14) | 1154 |
| Colour Index | 75160 |
| MDL Number | MFCD00031743 |
Specifications
| Appearance | Light yellow to Yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 %(calcd.on anh.substance) |
| Solubility in Water | almost transparency |
| Water | 9.5 to 16.0 % |
Properties (reference)
| Solubility in water | Soluble |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H301 + H311 + H331 : Toxic if swallowed, in contact with skin or if inhaled. |
| Precautionary Statements | P261 : Avoid breathing dust. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P302 + P352 + P312 : IF ON SKIN: Wash with plenty of water. Call a POISON CENTER/doctor if you feel unwell. P403 + P233 : Store in a well-ventilated place. Keep container tightly closed. |
Related Laws:
| EC Number | 206-258-2 |
| RTECS# | DR9867300 |
Transport Information:
| UN Number | UN1544 |
| Class | 6.1 |
| Packing Group | III |
| HS Number | 2939799090 |
Application
Autophagy research / Mitophagy research / ER-phagy research
References
- Berberine Induces Mitophagy through Adenosine Monophosphate-Activated Protein Kinase and Ameliorates Mitochondrial Dysfunction in PINK1 Knockout Mouse Embryonic Fibroblasts
- Berberine Rescues D-Ribose-Induced Alzheimer‘s Pathology via Promoting Mitophagy
- Berberine suppresses influenza virus-triggered NLRP3 inflammasome activation in macrophages by inducing mitophagy and decreasing mitochondrial ROS
- Berberine protects steatotic donor undergoing liver transplantation via inhibiting endoplasmic reticulum stress-mediated reticulophagy
- Berberine Ameliorates High Glucose-Induced Cardiomyocyte Injury via AMPK Signaling Activation to Stimulate Mitochondrial Biogenesis and Restore Autophagic Flux
Application
Bone research
References
- Berberine Promotes Osteoblast Differentiation by Runx2 Activation With p38 MAPK
- Berberine inhibits RANKL-induced osteoclast formation and survival through suppressing the NF-κB and Akt pathways
Application
Efflux pump inhibitor
Berberine can potentially inhibit a diverse range of different efflux pumps, including the resistance nodulation division (RND) family. 1,2)
References
- 1) Identification of natural compounds which inhibit biofilm formation in clinical isolates of Klebsiella pneumoniae.
- 2) Effectiveness of efflux pump inhibitors as biofilm disruptors and resistance breakers in gram-negative (ESKAPEE) bacteria
Application
Berberine Sulfate: An Isoquinoline Alkaloid with Multispectrum Activities
Berberine sulfate is an isoquinoline alkaloid extracted from many plants as with berberine chloride [B0450], another formulation. Recent pharmacological studies on berberine sulfate have revealed its various pharmacological activities, including antimicrobial1) and antineoplastic properties2). In addition, a comparative study of the dissolution properties of berberine in hydrochloride, sulfate and iodide salts has been reported3). (The product is for research purpose only.)
References
- 1) Berberine sulfate: antimicrobial activity, bioassay, and mode of action
- 2) Berberine inhibits the growth of human colorectal adenocarcinoma in vitro and in vivo
- 3) Dissolution properties of salt forms of berberine
PubMed Literature
Articles/Brochures
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