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Published TCIMAIL newest issue No.197
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CAS RN: 30516-87-1 | Product Number: A2052
3'-Azido-3'-deoxythymidine
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Purity: >98.0%(T)
Synonyms:
- Azidothymidine
- AZT
- 1-(3-Azido-2,3-dideoxy-β-D-ribofuranosyl)thymine
- Zidovudine
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 1G |
€27.00
|
3 | ≥40 |
|
| 5G |
€87.00
|
1 | 14 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
Supplemental Product Information:
This product is a sample for RUO (research use only). Do not use this product for any purpose other than testing and research.
| Product Number | A2052 |
| Purity / Analysis Method | >98.0%(T) |
| Molecular Formula / Molecular Weight | C__1__0H__1__3N__5O__4 = 267.25 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Hygroscopic |
| Packaging and Container | 1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 30516-87-1 |
| Reaxys Registry Number | 3595791 |
| PubChem Substance ID | 87559740 |
| SDBS (AIST Spectral DB) | 51948 |
| Merck Index (14) | 10123 |
| MDL Number | MFCD00006536 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(Neutralization titration) | min. 98.0 % |
| Melting point | 122.0 to 126.0 °C |
| Specific rotation [a]20/D | +43.0 to +51.0 deg(C=1, H2O) |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 124 °C |
| Specific Rotation | 47° (C=1,H2O) |
| Solubility in water | Slightly soluble |
| Degree of solubility in water | 20 g/l 25 °C |
| Solubility (soluble in) | Ethanol |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H351 : Suspected of causing cancer. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up. |
Related Laws:
| RTECS# | XP2072000 |
Transport Information:
| HS Number | 2940000080 |
Application
CRISPR Genome Editing / Research on regenerative medicine
Reference
- Small Molecules Enhance CRISPR Genome Editing in Pluripotent Stem Cells
Application
ortho-Selective C-H Silylation of Aryl Compounds Using an Iridium Catalyst
References
- Clicking 3'-Azidothymidine into Novel Potent Inhibitors of Human Immunodeficiency Virus
Application
A Synthetic Building Block of Rilpivirine
References
- Synthesis and Antitumor Activities of Novel 1,2,3-Triazole-fused Oligoconjugates Based on Nucleoside and Saccharide
Application
Zidovudine (AZT): a Nucleotide Reverse Transcriptase Inhibitor (NRTI)
3'-Azido-2',3'-dideoxythymidine (AZT, Zidovudine) is a nucleotide reverse transcriptase inhibitor (NRTI). It shows activity against human immunodeficiency virus (HIV). In 1985, AZT was found to inhibit the HIV in vitro (Mitsuya et al.). AZT, after conversion to AZT-5'-triphosphate (AZT-TP) by cellular enzymes, inhibits HIV-reverse transcriptase (HIV-RT).
References
- 3'-Azido-3'-deoxythymidine (BW A509U): an antiviral agent that inhibits the infectivity and cytopathic effect of human T-lymphotropic virus type III/lymphadenopathy-associated virus in vitro
- Phosphorylation of 3'-azido-3'-deoxythymidine and selective interaction of the 5'-triphosphate with human immunodeficiency virus reverse transcriptase
- AIDS-driven nucleoside chemistry.
- The bottleneck in AZT activation
- Anti-HIV drugs: 25 compounds approved within 25 years after the discovery of HIV
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TCIMAIL
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