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CAS RN: 3650-09-7 | Product Number: C2488
Carnosic Acid (Synthetic)
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Purity: >97.0%(T)(HPLC)
Synonyms:
- (4aR,10aS)-5,6-Dihydroxy-7-isopropyl-1,1-dimethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthrene-4a-carboxylic Acid (Synthetic)
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 20MG |
€62.00
|
2 | 34 |
|
| 100MG |
€200.00
|
2 | 33 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | C2488 |
| Purity / Analysis Method | >97.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__2__0H__2__8O__4 = 332.44 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (<0°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Light Sensitive,Air Sensitive,Heat Sensitive |
| Packaging and Container | 20MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 3650-09-7 |
| Reaxys Registry Number | 2707918 |
| PubChem Substance ID | 125307807 |
| MDL Number | MFCD02259459 |
Specifications
| Appearance | White to Yellow powder to crystal |
| Purity(HPLC) | min. 97.0 area% |
| Purity(Neutralization titration) | min. 97.0 % |
| Specific rotation [a]20/D | +182 to +195 deg(C=1, MeOH) |
Properties (reference)
| Melting Point | 190 °C |
| Specific Rotation | 184° (C=1,MeOH) |
GHS
Related Laws:
Transport Information:
| HS Number | 2918290090 |
Application
Efflux pump research / Efflux pump inhibitor
Carnosic acid is a compound known as an abietane diterpene. According to the study using Staphylococcus aureus, carnosic acid (10 μg/ml) showed a 2-fold potentiation of tetracycline activity against XU212 (TetK possessing strain) and 8-fold potentiation of erythromycin activity against RN4220 (Msr possessing strain).1)
(The product is for research purpose only.)
(The product is for research purpose only.)
Reference
- 1) Antibacterial and resistance modifying activity of Rosmarinus officinalis
- Rosmarinus officinalis as an Antioxidant
- Antioxidant Activity of a Rosemary Extract and Its Constituents, Carnosic Acid, Carnosol, and Rosmarinic Acid, in Bulk Oil and Oil-in-Water Emulsion
- Carnosic acid, a catechol-type electrophilic compound, protects neurons both in vitro and in vivo through activation of the Keap1/Nrf2 pathway via S-alkylation of targeted cysteines on Keap1
- Carnosic acid and carnosol inhibit adipocyte differentiation in mouse 3T3-L1 cells through induction of phase2 enzymes and activation of glutathione metabolism
- Carnosic acid and carnosol potently inhibit human 5-lipoxygenase and suppress pro-inflammatory responses of stimulated human polymorphonuclear leukocytes
- Carnosic acid, a new class of lipid absorption inhibitor from sage
- 1)M. Tada, T. Ohkanda, J. Kurabe, Chem. Pharm. Bull. 2010, 58, 27.
- 2)M. Tada, PCT Int. Appl. WO 2009060547, 2009.
- 3)M. Tada, TCIMAIL 2012, number 150, 2.
Application
Notice
This product is the synthetic carnosic acid. For your reference, recent reviews on carnosic acid after 2015 are shown on anther carnosic acid [C3477] product application on the website. (The product is for research purpose only.)
Application
Antioxidant study
References
Application
Neuron protective effects study
Reference
Application
Inhibition of adipocyte differentiation study
Reference
Application
Inhibition of human 5-Lipoxigenase study
Reference
Application
Inhibition of lipid absorption study
Reference
Application
Synthesis of carnosic acid
Reference
PubMed Literature
Articles/Brochures
TCIMAIL
[TCIMAIL No.153] Antioxidant Carnosic Acid by Chemical Synthesis[Product Highlights] Antioxidant Carnosic Acid by Chemical Synthesis
Product Documents (Note: Some products will not have analytical charts available.)
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Specifications
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Other Documents
Related Products
Carnosic Acid
| Product # | C3477 |
| CAS RN | 3650-09-7 |
| Purity / Analysis Method: | >97.0%(T)(HPLC) |