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CAS RN: 26833-87-4 | Product Number: H1775
Homoharringtonine
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Purity: >98.0%(HPLC)
Synonyms:
- Cephalotaxine 4-Methyl (2R)-2-Hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate
- O3-[(2R)-2,6-Dihydroxy-2-(2-methoxy-2-oxoethyl)-6-methylheptanoyl]cephalotaxine
Product Documents:
| Size | Unit Price | Shanghai | Tianjin | Japan* |
|---|---|---|---|---|
| 10MG |
¥790.00
|
Contact Us | Contact Us | 11 |
| 50MG |
¥2,050.00
|
Contact Us | Contact Us | 19 |
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| Product Number | H1775 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__9H__3__9NO__9 = 545.63 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| CAS RN | 26833-87-4 |
| Reaxys Registry Number | 5687925 |
| PubChem Substance ID | 468592045 |
| MDL Number | MFCD05618221 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Melting point | 144.0 to 148.0 °C |
| Specific rotation | -119 to -125deg (C=0.3, CHCl3) |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 146 °C |
GHS
| Pictogram |
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| Signal Word | Danger |
| Hazard Statements | H300 : Fatal if swallowed. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
Related Laws:
| RTECS# | FK0260000 |
Transport Information:
| UN Number | UN1544 |
| Class | 6.1 |
| Packing Group | II |
| Customs Control Conditions (Q) | Q类 （糖类，生物碱类，抗生素类，激素类） |
Application
Homoharringtonine: A Cephalotaxine Alkaloid with Antiviral and Anticancer Activities
Homoharringtonine is a cephalotaxine alkaloid originally found in Cephalotaxus hainanensis L.1) Homoharringtonine exhibits antiviral and anticancer activities, and immobilized ribosomes immediately after initiation of translation in eukaryotic systems. It has been reported that homoharringtonine induces apoptosis in human promyelocytic leukemic HL-60 cells.2,3) Therefore, homoharringtonine has been used for the treatment of chronic myeloid leukemia (CML). (The product is for research purpose only.)
References
- 1) Structures of harringtonine, isoharringtonine, and homoharringtonine
- 2) Homoharringtonine: history, current research, and future direction (a review)
- 3) Homoharringtonine, omacetaxine mepesuccinate, and chronic myeloid leukemia circa 2009 (a review)
- 4) From traditional Chinese medicine to traditional cancer therapy (a review)
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