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Building Block for Oxazolidinones

No.120(June 2004)
M1451
(R)-(+)-4-(Methoxymethyl)-1,3-dioxolan-2-one (1)
M1456
(S)-(-)-4-(Methoxymethyl)-1,3-dioxolan-2-one (2)
4-(Methoxymethyl)-1,3-dioxolan-2-one 1 and 2 are important building blocks that can be converted to chiral oxazolidinones. Jegham and coworkers have used 1 and 2 to synthesize chiral inhibitor analogs of monoamine oxidase 3, which is implicated in the degradation of various amine neurotransmitters.

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