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Published TCIMAIL newest issue No.197
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Monoclonal Antibody (LY111) Recognizing Chondroitin Sulfate A
No.175(October 2017)
The monoclonal antibody 1 binds to chondroitin sulfate A, a type of glycosaminoglycan. It has been reported that chondroitin sulfates are ubiquitous in various tissues such as cartilage, cornea, and brain, and are involved in moisture regulation and cell adhesion, as well the immune system. 1 preferentially recognizes chondroitin sulfate A, which bares a sulfate at 4-position of GalNAc (2).1)
References
- 1)Structural determination of novel sulfated octasaccharides isolated from chondroitin sulfate of shark cartilage and their application for characterizing monoclonal antibody epitopes
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