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Published TCIMAIL newest issue No.197
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Zwitterionic Monomer for the Synthesis of Biocompatible Polymers
3-[[2-(Methacryloyloxy)ethyl]dimethylammonio]propionate (CBMA) is a zwitter ionic methacrylate ester with a quaternary ammonium group and a carboxyl group in the molecule. CBMA has been reported to be applied to biomaterials, just like 2-methacryloyloxyethyl phosphorylcholine (MPC) which is well known as a useful monomer for the synthesis of biocompatible polymers. For example, Jiang et al. have added repellency of protein adsorption to a glass surface by polymerizing the CBMA after modifying an atom-transfer radical polymerization (ATRP) initiator on the glass surface.1) Besides, CBMA has been used in the research of polymer modification on a gold surface,2) hydrogel implants resisting the foreign-body reaction,3) and drug delivery vehicles conjugating with an anticancer agent.4)
References
- 1)Superlow fouling sulfobetaine and carboxybetaine polymers on glass slides
- 2)Dual-functional biomimetic materials: nonfouling poly(carboxybetaine) with active functional groups for protein immobilization
- 3)Zwitterionic hydrogels implanted in mice resist the foreign-body reaction
- 4)Development of zwitterionic polymer-based doxorubicin conjugates: tuning the surface charge to prolong the circulation and reduce toxicity
