CAS RN: 6846-35-1 | Product Number: X0001

Xanthane Hydride

Purity: >96.0%(HPLC)

Synonyms:

ADTT
5-Amino-3H-1,2,4-dithiazole-3-thione
3-Amino-1,2,4-dithiazole-5-thione
5-Imino-5H-[1,2,4]dithiazole-3-thiol

Product Documents:

Size	Unit Price	Belgium	Japan*
25G	£53.00	2	≥40
100G	£144.00	≥40	20
500G	£462.00	≥100	≥100

*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).

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General Information plus

Product Number	X0001
Purity / Analysis Method	>96.0%(HPLC)
Molecular Formula / Molecular Weight	C__2H__2N__2S__3 = 150.23
Physical State (20 deg.C)	Solid
Storage Temperature	Room Temperature (Recommended in a cool and dark place, <15°C)
CAS RN	6846-35-1
Reaxys Registry Number	112403
PubChem Substance ID	87577871
SDBS (AIST Spectral DB)	3701
MDL Number	MFCD00051660

Specifications & Properties plus

Specifications

Appearance	Light yellow to Brown powder to crystal
Purity(HPLC)	min. 96.0 area%
Purity(with Total Nitrogen)	min. 96.0 %

Properties (reference)

Safety & Regulations plus

GHS

Pictogram
Signal Word	Warning
Hazard Statements	H315 : Causes skin irritation. H319 : Causes serious eye irritation.
Precautionary Statements	P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention.

Related Laws:

EC Number	229-933-3
RTECS#	JO6500000

Transport Information:

HS Number

2934999090

Applications & Literature plus

Application

Sulfur-Transfer Reagents for Synthesis of Oligonucleotide Phosphorothioates

References

Nucleic acid therapeutics: basic concepts and recent developments
- V. K. Sharma, P. Rungta, A. K. Prasad, RSC Adv. 2014, 4, 16618.
3H-1,2-Benzodithiol-3-one 1,1-dioxide
- S. L. Beaucage, e-EROS Encycl. Reagents Org. Synth. 2012, 1.
Phosphorothioate Oligonucleotides with Low Phosphate Diester Content: Greater than 99.9% Sulfurization Efficiency with “Aged” Solutions of Phenylacetyl Disulfide (PADS)
- A. H. Krotz, D. Gorman, P. Mataruse, C. Foster, J. D. Godbout, C. C. Coffin, A. N. Scozzari, Org. Proc. Res. Dev. 2004, 8, 852.
Large-Scale Synthesis of Oligonucleotide Phosphorothioates Using 3-Amino-1,2,4-dithiazole-5-thione as an Efficient Sulfur-Transfer Reagent
- J.-Y. Tang, Y. Han, J. X. Tang, Z. Zhang, Org. Proc. Res. Dev. 2000, 4, 194.
Mechanism of the sulfurisation of phosphines and phosphites using 3-amino-1,2,4-dithiazole-5-thione (xanthane hydride)
- J. Hanusek, M. A. Russell, A. P. Laws, P. Jansa, J. H. Atherton, K. Fettesd, M. I. Page, Org. Biomol. Chem. 2007, 5, 478.

Application

Xanthane Hydride: A Sulfur-Transfer Reagent for Synthesis of Oligonucleotide Phosphorothioates

Xanthane hydride (3-amino-1,2,4-dithiazole-5-thione), Beaucage Reagent [B3125] and Bis(phenylacetyl) disulfide [B3623] are used as a sulfur-transfer reagent for synthesis of oligonucleotide phosphorothioates via the phosphoramidite method.^1-4) In particular, xanthane hydride has advantages because it does not yield oxidizing substances, carbon disulfide and cyanamide as the additional reaction products.^2,3) For DNA/RNA synthesizer, xanthane hydride solution is used, such as 0.02 M solution in acetonitrile/pyridine (9:1),¹⁾ or 0.20 M solution in pyridine.⁴⁾