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CAS RN: 19545-26-7 | Product Number: W0007
Wortmannin
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Purity: >98.0%(HPLC)
Synonyms:
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 20MG |
£66.00
|
1 | 21 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | W0007 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__3H__2__4O__8 = 428.44 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (-20°C) |
| Condition to Avoid | Light Sensitive,Heat Sensitive |
| CAS RN | 19545-26-7 |
| Reaxys Registry Number | 67676 |
| PubChem Substance ID | 253659701 |
| Merck Index (14) | 10053 |
| MDL Number | MFCD00133927 |
Specifications
| Appearance | White to Yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Melting point | 236.0 to 240.0 °C |
| Specific rotation | +85.0 to +95.0 deg(C=0.17,CHCl3) |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 237 °C |
| Maximum Absorption Wavelength | 296 nm |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H300 + H310 + H330 : Fatal if swallowed, in contact with skin or if inhaled. |
| Precautionary Statements | P260 : Do not breathe dust. P262 : Do not get in eyes, on skin, or on clothing. P280 : Wear protective gloves/ protective clothing. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P302 + P352 + P310 : IF ON SKIN: Wash with plenty of water. Immediately call a POISON CENTER/doctor. P304 + P340 + P310 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Immediately call a POISON CENTER/doctor. P403 + P233 : Store in a well-ventilated place. Keep container tightly closed. |
Related Laws:
| RTECS# | CB9641000 |
Transport Information:
| UN Number | UN3462 |
| Class | 6.1 |
| Packing Group | I |
| HS Number | 2932209090 |
Application
Type IV secretion system (T4SS) research
Reference
- Chemical Genetics Reveals Bacterial and Host Cell Functions Critical for Type IV Effector Translocation by Legionella pneumophila
Application
Studies of Phosphatidylinositol 3-Kinase (PI3K) Inhibition by Wortmannin
References
- Essential role of phosphatidylinositol 3-kinase in insulin-induced glucose transport and antilipolysis in rat adipocytes. Studies with a selective inhibitor wortmannin
- T. Okada, Y. Kawano, T. Sakakibara, O. Hazeki, M. Ui, J. Biol. Chem. 1994, 269, 3568.
- Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: The role of phosphatidylinositol 3,4,5-triphosphate in neutrophil responses
- A. Arcaro, M. P. Wymann, Biochem. J. 1993, 296, 297.
- Structural determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin, and staurosporine
- Targeting the PI3K-Akt pathway in human cancer: Rationale and promise
Application
PI3K Inhibitor
References
- 1)Historical landmarks of autophagy research
- 2)Autophagy: renovation of cells and tissues
- 3)Regulation of autophagy by kinases
- 4)Two distinct Vps34 phosphatidylinositol 3-kinase complexes function in autophagy and carboxypeptidase Y sorting in Saccharomyces cerevisiae
- 5)Beclin-phosphatidylinositol 3-kinase complex functions at the trans-Golgi network
- 6)Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses
- 7)The phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 inhibit autophagy in isolated rat hepatocytes
- 8)Variation in the safety of induced pluripotent stem cell lines
- 9)PI3K/AKT signaling pathway is essential for survival of induced pluripotent stem cells
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