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CAS RN: 152-11-4 | Product Number: V0118
Verapamil Hydrochloride
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Purity: >98.0%(T)(HPLC)
Synonyms:
- 5-[(3,4-Dimethoxyphenethyl)methylamino]-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile Hydrochloride
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 5G |
£39.00
|
2 | ≥100 |
|
| 25G |
£134.00
|
3 | ≥40 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | V0118 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__2__7H__3__8N__2O__4·HCl = 491.07 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Condition to Avoid | Light Sensitive |
| CAS RN | 152-11-4 |
| Related CAS RN | 52-53-9 |
| Reaxys Registry Number | 3647093 |
| PubChem Substance ID | 253660291 |
| Merck Index (14) | 9950 |
| MDL Number | MFCD00055208 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 143.0 to 147.0 °C |
Properties (reference)
| Melting Point | 145 °C |
| Solubility in water | Slightly soluble |
| Solubility (soluble in) | Ethanol, Methanol |
| Solubility (insoluble in) | Ether |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H301 + H311 + H331 : Toxic if swallowed, in contact with skin or if inhaled. H360 : May damage fertility or the unborn child. H362 : May cause harm to breast-fed children. |
| Precautionary Statements | P263 : Avoid contact during pregnancy and while nursing. P260 : Do not breathe dust. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P403 + P233 : Store in a well-ventilated place. Keep container tightly closed. |
Related Laws:
| EC Number | 205-800-5 |
| RTECS# | YV8320000 |
Transport Information:
| UN Number | UN2811 |
| Class | 6.1 |
| Packing Group | III |
| HS Number | 2926907090 |
Application
Lentivirus vector transduction enhancer
Verapamil increases transduction by VSV-G–pseudotyped lentiviral vectors.1)
References
- 1) ABC transporter inhibitors that are substrates enhance lentiviral vector transduction into primitive hematopoietic progenitor cells
Application
Verapamil Hydrochloride: The First Calcium-Channel Antagonist (Blocker)
Calcium channel antagonists (blockers) are chemicals that disrupt the movement of calcium ion (Ca2+) through calcium channels in the cell membrane. Verapamil hydrochloride, which is the first calcium channel antagonist, prolongs atrioventricular (A-V) conduction (A-H interval) in a dose-dependent manner. It is an effective antianginal agent when directly compared with a β-blocker, and is more effective in reducing myocardial ischemia compared with amlodipine monotherapy. Recently, various formulations have been reported to achieve efficient drug incorporation with a satisfactory in vitro drug release rate. (The product is for research purpose only.)
References
- Comparative pharmacology of calcium antagonists: nifedipine, verapamil and diltiazem
- Verapamil (a review of its pharmacological properties and therapeutic use in coronary artery disease)
- The effect of the drug/polymer ratio on the properties of the verapamil HCl loaded microspheres
- Controlled release of verapamil hydrochloride from waxy microparticles prepared by spray congealing
- Swelling studies and in vitro release of verapamil from calcium alginate and calcium alginate-chitosan beads
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