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Published TCIMAIL newest issue No.197
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CAS RN: 481-53-8 | Product Number: T2708
Tangeretin
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Purity: >96.0%(HPLC)
Synonyms:
- 4',5,6,7,8-Pentamethoxyflavone
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 10MG |
£93.00
|
1 | ≥80 |
|
| 100MG |
£587.00
|
Contact Us | 35 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | T2708 |
| Purity / Analysis Method | >96.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__0H__2__0O__7 = 372.37 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container | 10MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 481-53-8 |
| Reaxys Registry Number | 351695 |
| PubChem Substance ID | 125307389 |
| MDL Number | MFCD00017438 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 96.0 area% |
| Melting point | 153.0 to 157.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 155 °C |
GHS
Related Laws:
| EC Number | 207-570-1 |
| RTECS# | DJ3102725 |
Transport Information:
| HS Number | 2932990090 |
Application
Tangeretin: A Polymethoxylated Flavonoid with Anticancer and Antioxidant Activities
Tangeretin, a polymethoxylated flavonoid contained in peels of citrus fruits, is known to have anticancer and antioxidant activities. Recent studies have shown that tangeretin induces cell-cycle G1 arrest, and suppresses cyclooxygenase-2 (COX-2) expression. (The product is for research purpose only.)
References
- Tangeretin induces cell-cycle G1 arrest through inhibiting cyclin-dependent kinases 2 and 4 activities as well as elevating Cdk inhibitors p21 and p27 in human colorectal carcinoma cells
- Tangeretin and nobiletin induce G1 cell cycle arrest but not apoptosis in human breast and colon cancer cells
- Methoxylated flavones, a superior cancer chemopreventive flavonoid subclass? (a review)
- Tangeretin suppresses IL-1beta-induced cyclooxygenase (COX)-2 expression through inhibition of p38 MAPK, JNK, and AKT activation in human lung carcinoma cells
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