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CAS RN: 64461-82-1 | Product Number: T2527
Tizanidine Hydrochloride
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Purity: >98.0%(T)(HPLC)
Synonyms:
- 5-Chloro-4-[(4,5-dihydro-1H-imidazol-2-yl)amino]-2,1,3-benzothiadiazole Hydrochloride
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 5G |
£30.00
|
Contact Us | ≥40 |
|
| 25G |
£94.00
|
1 | ≥40 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | T2527 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__9H__8ClN__5S·HCl = 290.17 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 64461-82-1 |
| Related CAS RN | 51322-75-9 |
| Reaxys Registry Number | 6022764 |
| PubChem Substance ID | 87560328 |
| Merck Index (14) | 9485 |
| MDL Number | MFCD00798231 |
Specifications
| Appearance | White to Yellow to Orange powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
Properties (reference)
| Melting Point | 280 °C |
| Solubility in water | Soluble |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
Related Laws:
| RTECS# | DK9910000 |
Transport Information:
| HS Number | 2934999090 |
Application
Tizanidine Hydrochloride: A Centrally Acting α2-Adrenergic Receptor Agonist
Tizanidine hydrochloride is a centrally acting α2-adrenergic receptor agonist and presumably reduces spasticity of the muscles by increasing presynaptic inhibition of motor neurons. Tizanidine is mainly metabolized by cytochrome P450 (CYP) 1A2. Tizanidine is widely used to manage spasticity caused by multiple sclerosis (MS), acquired brain injury and spinal cord injury (SCI). In addition, some fast dissolving tablets of tizanidine hydrochloride have been developed. (The product is for research purpose only.)
References
- Tizanidine: a review of its pharmacology, clinical efficacy and tolerability in the management of spasticity associated with cerebral and spinal disorders
- Tizanidine is mainly metabolized by cytochrome P450 1A2 in vitro
- Formulation, evaluation and optimization of fast dissolving tablet containing Tizanidine Hydrochloride
- Application of HPLC and HPTLC for the simultaneous determination of tizanidine and rofecoxib in pharmaceutical dosage form
- Simultaneous RP-HPLC estimation of tizanidine, diclofenac potassium, and paracetamol in tablets
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