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Published TCIMAIL newest issue No.197
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CAS RN: 6533-68-2 | Product Number: S0021
Scopolamine Hydrobromide Trihydrate
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Purity: >98.0%(T)(HPLC)
Synonyms:
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 1G |
£62.00
|
1 | ≥80 |
|
| 10G |
£473.00
|
1 | ≥60 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | S0021 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__7H__2__1NO__4·HBr·3H__2O = 438.32 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Condition to Avoid | Light Sensitive |
| Packaging and Container | 1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 6533-68-2 |
| Related CAS RN | 114-49-8&51-34-3 |
| Reaxys Registry Number | 6100669 |
| PubChem Substance ID | 87575651 |
| Merck Index (14) | 8406 |
| MDL Number | MFCD00012647 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 %(after drying) |
| Specific rotation [a]20/D | -24.0 to -27.0 deg(C=5, H2O)(after drying) |
| Solubility in Water | almost transparency |
| Drying loss | max. 13.0 % |
Properties (reference)
| Melting Point | 195 °C |
| Specific Rotation | -25.5° (C=5,H2O) |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H310 + H330 : Fatal in contact with skin or if inhaled. H302 : Harmful if swallowed. |
| Precautionary Statements | P260 : Do not breathe dust. P262 : Do not get in eyes, on skin, or on clothing. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing. P302 + P352 + P310 : IF ON SKIN: Wash with plenty of water. Immediately call a POISON CENTER/doctor. P304 + P340 + P310 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Immediately call a POISON CENTER/doctor. P403 + P233 : Store in a well-ventilated place. Keep container tightly closed. |
Related Laws:
| EC Number | 204-050-6 |
| RTECS# | YM4550000 |
Transport Information:
| UN Number | UN1544 |
| Class | 6.1 |
| Packing Group | III |
| HS Number | 2939799090 |
Application
Scopolamine Hydrobromide: A Belladonna Alkaloid with Anticholinergic Activity
Scopolamine salts ([S0021][ S0230] and [S0231]) and N-oxide [S0229], belladonna alkaloids, are anticholinergic agents. Their free base, scopolamine competitively inhibits muscarinic receptors of the parasympathetic nervous system for acetylcholine and act as a nonselective muscarinic antagonist, producing peripheral anti-muscarinic, central sedative and antiemetic effects. The parasympatholytic scopolamine, structurally very similar to atropine [A0754] as well, is used in conditions requiring decreased parasympathetic activity. Therefore, scopolamine can inhibit the secretion of saliva and sweat, decrease gastrointestinal secretions and motility, and increase heart rate et al. (The product is for research purpose only.)
References
- The validity of scopolamine as a pharmacological model for cognitive impairment: A review of animal behavioral studies (a review)
- Analytical profile of scopolamine hydrobromide (a review on description, synthesis, physical properties, analytical stability and storage, pharmacology, and pharmacokinetics)
- HPLC determination of atropine sulfate and scopolamine hydrobromide in pharmaceuticals
- Fatal Datura poisoning: identification of atropine and scopolamine by high performance liquid chromatography/photodiode array/mass spectrometry
Application
Reagent for experimental amnesia (Alzheimer's disease) model
References
- Ameliorative effects of azaindolizinone derivative ZSET845 on scopolamine-induced deficits in passive avoidance and radial-arm maze learning in the rat
- Scopolamine as an antidepressant: a systematic review
- Antidepressant effects of the muscarinic cholinergic receptor antagonist scopolamine: a review
PubMed Literature
Articles/Brochures
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