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Published TCIMAIL newest issue No.197
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CAS RN: 138-52-3 | Product Number: S0003
Salicin
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Purity: >98.0%(HPLC)
Synonyms:
- 2-(Hydroxymethyl)phenyl β-D-Glucopyranoside
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 5G |
£27.00
|
3 | ≥60 |
|
| 25G |
£85.00
|
1 | 14 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | S0003 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__3H__1__8O__7 = 286.28 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 138-52-3 |
| Reaxys Registry Number | 89593 |
| PubChem Substance ID | 87575634 |
| SDBS (AIST Spectral DB) | 3003 |
| Merck Index (14) | 8324 |
| MDL Number | MFCD00006590 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Melting point | 199.0 to 202.0 °C |
| Specific rotation [a]20/D | -60.0 to -64.0 deg(C=3, H2O) |
Properties (reference)
| Melting Point | 200 °C |
| Specific Rotation | -62° (C=3,H2O) |
| Solubility in water | Soluble |
| Solubility (insoluble in) | Ether, Chloroform |
GHS
Related Laws:
| EC Number | 205-331-6 |
| RTECS# | LZ5901700 |
Transport Information:
| HS Number | 2938909090 |
Application
Salicin: An Alcoholic β-Glucoside Derived from Willow Bark with Anti-Inflammatory Activity
Salicin is an alcoholic β-glucoside derived from willow bark which has been traditionally used as an anti-inflammatory, antipyretic, and analgesic medicine.1,2) Salicin acts as a non-selective COX inhibitor, and effects very similar to acetylsalicylic acid [A2262].3) Recently, various studies have demonstrated that the anti-inflammatory activity of willow bark extract is associated with down regulation of the inflammatory mediators tumor necrosis factor-α and nuclear factor-kappa B.2) In addition, some studies have been reported that salicin acts as an agonist on the bitter taste receptor, TAS2R16.4) (The product is for research purpose only.)
References
- 1) Willow bark extract: the contribution of polyphenols to the overall effect (a review)
- 2) Efficacy and Safety of White Willow Bark (Salix alba) Extracts (a review)
- 3) Structural and Functional Basis of Cyclooxygenase Inhibition
- 4) The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides
PubMed Literature
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