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CAS RN: 446859-33-2 | Product Number: R0224
RepSox
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Purity: >98.0%(HPLC)
Synonyms:
- ALK 5 Inhibitor II
- 2-[3-(6-Methylpyridin-2-yl)-1H-pyrazol-4-yl]-1,5-naphthyridine
- TGF-β RI Kinase Inhibitor II
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 5MG |
£52.00
|
1 | ≥40 |
|
| 25MG |
£204.00
|
1 | 22 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | R0224 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__7H__1__3N__5 = 287.33 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (<0°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 446859-33-2 |
| Reaxys Registry Number | 9782770 |
| PubChem Substance ID | 468592794 |
| MDL Number | MFCD09037561 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Melting point | 193.0 to 197.0 °C |
Properties (reference)
| Melting Point | 195 °C |
GHS
Related Laws:
Transport Information:
| HS Number | 2933399990 |
Application
TGF-β Type I Receptor Inhibitor
RepSox (1) is a cell permeable TGF-β type I receptor inhibitor. 1 shows inhibition properties on ALK5 as shown in Table 1 and less potent activity against 9 other related kinases, including p38 MAPK, JNK1, and GSK3 (IC50 > 16 μM).1) 1 promotes reprogramming of human and mouse embryonic fibroblasts to induced pluripotent stem cells (iPSCs).2,3) In addition, it was also reported that 1 induces human ESCs and iPSCs into glucagon-producing cells and insulin-producing cells, respectively.4,5)
References
- 1) Identification of 1,5-naphthyridine derivatives as a novel series of potent and selective TGF-β type I receptor inhibitors
- 2) A small-molecule inhibitor of Tgf-β signaling replaces Sox2 in reprogramming by inducing Nanog
- 3) Multiple targets of miR-302 and miR-372 promote reprogramming of human fibroblasts to induced pluripotent stem cells
- 4) Small molecules induce efficient differentiation into insulin-producing cells from human induced pluripotent stem cells
- 5) Production of functional glucagon-secreting α-cells from human embryonic stem cells
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