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CAS RN: 162401-32-3 | Product Number: R0193
Roflumilast
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Purity: >98.0%(HPLC)
Synonyms:
- 3-(Cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 250MG |
£52.00
|
1 | 20 |
|
| 1G |
£158.00
|
18 | 27 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | R0193 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__7H__1__4Cl__2F__2N__2O__3 = 403.21 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (-20°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 162401-32-3 |
| Reaxys Registry Number | 9802592 |
| PubChem Substance ID | 354334855 |
| Merck Index (14) | 8249 |
| MDL Number | MFCD00938270 |
Specifications
| Appearance | White to Orange to Green powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(with Total Nitrogen) | min. 97.0 % |
| Melting point | 157.0 to 161.0 °C |
Properties (reference)
| Melting Point | 159 °C |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
Related Laws:
| RTECS# | CV3325600 |
Transport Information:
| HS Number | 2933399990 |
Application
Roflumilast: A Selective Phosphodiesterase 4 (PDE4) Inhibitor.
Roflumilast is a selective phosphodiesterase 4 (PDE4) inhibitor. The active metabolite, Roflumilast N-oxide [R0217], also acts as a selective PDE4 inhibitor. PDE4 is a key enzyme in the degradation of cyclic adenosine monophosphate (cyclic AMP) [A2381] and is centrally involved in the cytokine production of inflammatory cells. The inhibition of PDE4 activity leads to accumulation of intracellular cyclic AMP. Roflumilast is used for the treatment of chronic obstructive pulmonary disease (COPD). While the precise mechanism of the therapeutic action in COPD is not well defined, it is thought to be related to the effects of increased intracellular cyclic AMP in lung cells. For your reference, [C3395] and [D4505] are synthetic intermediates of roflumilast. (The product is for research purpose only.)
References
- Anti-inflammatory and immunomodulatory potential of the novel PDE4 inhibitor roflumilast in vitro
- Phosphodiesterase-4 inhibitors for asthma and chronic obstructive pulmonary disease (a review)
- The preclinical pharmacology of roflumilast - A selective, oral phosphodiesterase 4 inhibitor in development for chronic obstructive pulmonary disease (a review)
- Sensitive quantification of roflumilast and roflumilast N-oxide in human plasma by LC-MS/MS employing parallel chromatography and electrospray ionisation
- Isolation, synthesis and structure confirmation of the impurity in crude roflumilast product
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