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CAS RN: 57-66-9 | Product Number: P1975
Probenecid
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Purity: >98.0%(T)(HPLC)
Synonyms:
- 4-(N,N-Dipropylsulfamoyl)benzoic Acid
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 25G |
£49.00
|
3 | ≥100 |
|
| 100G |
£145.00
|
Contact Us | 19 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | P1975 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__3H__1__9NO__4S = 285.36 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 57-66-9 |
| Reaxys Registry Number | 2815775 |
| PubChem Substance ID | 160870945 |
| Merck Index (14) | 7754 |
| MDL Number | MFCD00038402 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
| Melting point | 198.0 to 202.0 °C |
Properties (reference)
| Melting Point | 200 °C |
| Solubility in water | Insoluble |
| Solubility (soluble in) | Alcohol, Acetone, Chloroform |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
Related Laws:
| EC Number | 200-344-3 |
| RTECS# | DG9400000 |
Transport Information:
| HS Number | 2935909099 |
Application
Probenecid: An Organic Anion Transport (OAT) Inhibitor
Probenecid is an organic anion transport inhibitor in the kidney and other organs. It was initially developed with the goal of reducing the renal excretion of antibiotics, specifically penicillin. Recently, it is used for its uricosuric properties in the treatment in gout. (The product is for research purpose only.)
References
- Inhibition of Fura-2 sequestration and secretion with organic anion transport blockers
- The History and Future of Probenecid
- Human UDP-glucuronosyltransferases: isoform selectivity and kinetics of 4-methylumbelliferone and 1-naphthol glucuronidation, effects of organic solvents, and inhibition by diclofenac and probenecid
- Mouse model of Parkinsonism: a comparison between subacute MPTP and chronic MPTP/probenecid treatment
- Probenecid reverses multidrug resistance in multidrug resistance-associated protein-overexpressing HL60/AR and H69/AR cells but not in P-glycoprotein-overexpressing HL60/Tax and P388/ADR cells
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