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Published TCIMAIL newest issue No.197
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CAS RN: 61-25-6 | Product Number: P0016
Papaverine Hydrochloride
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Purity: >99.0%(HPLC)
Synonyms:
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 25G |
£47.00
|
Contact Us | 14 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | P0016 |
| Purity / Analysis Method | >99.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__0H__2__1NO__4·HCl = 375.85 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Condition to Avoid | Light Sensitive |
| CAS RN | 61-25-6 |
| Reaxys Registry Number | 3921435 |
| PubChem Substance ID | 87574297 |
| Merck Index (14) | 7019 |
| MDL Number | MFCD00012745 |
Specifications
| Appearance | White powder to crystal |
| Purity(HPLC) | min. 99.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Solubility in Water | almost transparency |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 225 °C(dec.) |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H301 : Toxic if swallowed. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
Related Laws:
| EC Number | 200-502-1 |
| RTECS# | NW8575000 |
Transport Information:
| UN Number | UN1544 |
| Class | 6.1 |
| Packing Group | III |
| HS Number | 2939190000 |
Application
Papaverine Hydrochloride: An Isoquinoline Alkaloid with Smooth Muscle Relaxation Activity
Papaverine hydrochloride is an isoquinoline alkaloid obtained from opium or prepared synthetically. The most characteristic effect of papaverine is relaxation of the tonus of all smooth muscle. Pharmacological studies suggest that papaverine exerts its effect on by an inhibitory action on phosphodiesterase, resulting in increased intracellular cAMP as well as inhibition of voltage-gated calcium channels. (The product is for research purpose only.)
References
- Inhibition of cyclic-3',5'-nucleotide-phosphodiesterase as a possible mode of action of papaverine and similarly acting drugs
- Phosphodiesterase inhibitors
- On the mechanism of papaverine inhibition of the voltage-dependent Ca++ current in isolated smooth muscle cells from the guinea pig trachea
- Spectrophotometric determination of meclozine HCl and papaverine HCl in their pharmaceutical formulations
- Analytical profile of papaverine hydrochloride (a review on the desorption, physical properties, isolation, synthesis, biosynthesis, pharmacokinetics, stability, and determination of it)
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