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Published TCIMAIL newest issue No.197
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CAS RN: 85650-52-8 | Product Number: M2151
Mirtazapine
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Purity: >98.0%(HPLC)
Synonyms:
- 1,2,3,4,10,14b-Hexahydro-2-methylpyrazino[2,1-a]pyrido[2,3-c][2]benzazepine
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 100MG |
£29.00
|
5 | 8 |
|
| 1G |
£179.00
|
1 | 30 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | M2151 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__7H__1__9N__3 = 265.36 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Packaging and Container | 1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 85650-52-8 |
| Reaxys Registry Number | 549345 |
| PubChem Substance ID | 125307817 |
| SDBS (AIST Spectral DB) | 52906 |
| MDL Number | MFCD00865427 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 95.0 % |
| Melting point | 119.0 to 123.0 °C |
Properties (reference)
| Melting Point | 121 °C |
GHS
Related Laws:
| EC Number | 288-060-6 |
| RTECS# | UQ4410250 |
Transport Information:
| HS Number | 2933998090 |
Application
Mirtazapine: A Noradrenergic and Specific Serotonergic Antidepressant (NaSSA)
Mirtazapine (Org 3770) is the first noradrenergic and specific serotonergic antidepressant (NaSSA). Studies have suggested that mirtazapine acts as an antagonist at central presynaptic α2 adrenergic inhibitory autoreceptors and heteroreceptors, as well as by blocking 5-HT2 and 5-HT3 receptors. Therefore, these antagonisms enhance the release of noradrenaline and 5-HT1A-mediated serotonergic transmission in brain. Mirtazapine is mainly metabolized by CYP1A2, CYP2D6, and CYP3A4. (The product is for research purpose only.)
References
- Neurochemical and autonomic pharmacological profiles of the 6-aza-analog of mianserin, Org 3770 and its enantiomers
- Effect of the alpha-2 adrenoceptor antagonist mirtazapine on the 5-hydroxytryptamine system in the rat brain.
- A review of the pharmacological and clinical profile of mirtazapine
- High-Performance Liquid Chromatographic Method with Diode Array Detection for Identification and Quantification of the Eight New Antidepressants and Five of Their Active Metabolites in Plasma after Overdose
- Chirality in the New Generation of Antidepressants: Stereoselective Analysis of the Enantiomers of Mirtazapine, N-Demethylmirtazapine, and 8-Hydroxymirtazapine by LC-MS
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