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CAS RN: 15297-92-4 | Product Number: L0422
LDN-22684
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Purity: >98.0%(HPLC)
Synonyms:
- Dehydro-α-lapachone
- 2,2-Dimethyl-2H-naphtho[2,3-b]pyran-5,10-dione
- 2,2-Dimethyl-2H-benzo[g]chromene-5,10-dione
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 100MG |
£108.00
|
Contact Us | ≥40 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | L0422 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__5H__1__2O__3 = 240.26 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 15297-92-4 |
| Reaxys Registry Number | 181737 |
| MDL Number | MFCD00022286 |
Specifications
| Appearance | White to Yellow to Orange powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Melting point | 142.0 to 146.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 145 °C |
GHS
Related Laws:
Transport Information:
| HS Number | 2932990090 |
Application
LDN-22684: A LRRK2 Inhibitor as a Useful Tool for the Study of Parkinson's disease
The leucine-rich repeat kinase 2 (LRRK2) is a large protein (2527 amino acids) with serine-threonine (Ser/Thr) protein kinase activity and autophosphorylation activity. It is highly expressed in many mammal tissues. Genetic mutations in the G2019S encoding portion of LRRK2 (LRRK2-G2019S) have been detected frequently in Parkinson's (PD) patients.1-3) As a result, LRRK2-G2019S is a promising therapeutic target for the treatment of PD. There are reports, that LDN-22684 inhibited LRRK2-G2019S and wild-type LRRK2 in the low micromole range.1,3) Therefore it is a useful tool for the study of PD. (The product is for research purpose only.)
References
- 1) Small Molecule Kinase Inhibitors for LRRK2 and Their Application to Parkinson's Disease Models (a review)
- 2) Chemical Biology of Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitors (a review)
- 3) Development of a mechanism-based high-throughput screen assay for leucine-rich repeat kinase 2-Discovery of LRRK2 inhibitors
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