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CAS RN: 138402-11-6 | Product Number: I0859
Irbesartan
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Purity: >98.0%(T)(HPLC)
Synonyms:
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 1G |
£16.00
|
2 | ≥40 |
|
| 5G |
£43.00
|
1 | ≥40 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | I0859 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__2__5H__2__8N__6O = 428.54 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Packaging and Container | 1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 138402-11-6 |
| Reaxys Registry Number | 6620400 |
| PubChem Substance ID | 172088930 |
| Merck Index (14) | 5083 |
| MDL Number | MFCD00864464 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
| Melting point | 184.0 to 188.0 °C |
Properties (reference)
| Melting Point | 188 °C |
| Solubility in water | Insoluble |
GHS
| Hazard Statements | H413 : May cause long lasting harmful effects to aquatic life. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P273 : Avoid release to the environment. |
Related Laws:
| RTECS# | HM2950270 |
Transport Information:
| HS Number | 2933299090 |
Application
Selective AT1 Subtype Angiotensin II Receptor Antagonists
References
- Angiotensin Type 1 Receptor Blockers Induce Peroxisome Proliferator-Activated Receptor-gamma Activity
- Selective angiotensin II receptor antagonism reduces insulin resistance in obese Zucker rats
- Pharmacological characterization of SR 47436, a new nonpeptide AT1 subtype angiotensin II receptor antagonist
- C. Cazaubon, J. Gougat, F. Bousquet, P. Guiraudou, R. Gayraud, C. Lacour, A. Roccon, G. Galindo, G. Barthelemy, B. Gautret, J. Pharmacol. Exp. Ther. 1993, 265, 826.
- Role of cytochrome P-4502C9 in irbesartan oxidation by human liver microsomes
- M. Bourrié, V. Meunier, Y. Berger, G. Fabre, Drug Metab. Dispos. 1999, 27, 288.
Application
Irbesartan: A Long-Active Specific Competitive Angiotensin II Type 1 (AT1) Receptor Antagonist
Angiotensin II, a peptide hormone, is a potent vasoconstrictor formed from angiotensin I in a reaction catalyzed by angiotensin-converting enzyme (ACE). Angiotensin II can activate two different receptors, AT1 and AT2, both of which are coupled to G-protein. The most important vasoconstrictor actions of angiotensin II are mediated through AT1 receptors. Irbesartan is a long-active specific competitive antagonist of AT1 receptors with a much greater affinity for the AT1 receptor than for the AT2 receptor, and no agonist activity. Irbesartan selectively binds to the AT1 receptor and competitively binds the endogenous hypertensive (vasoconstrictor) substance angiotensin II, and has an antihypertensive effect. For your reference, [B4143] is a key synthetic intermediate of irbesartan. (The product is for research purpose only.)
References
- Irbesartan: a review of its pharmacodynamic and pharmacokinetic properties and therapeutic use in the management of hypertension
- The new angiotensin II receptor antagonist, irbesartan: pharmacokinetic and pharmacodynamics considerations (a review)
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