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CAS RN: 516-55-2 | Product Number: H1839
3β-Hydroxy-5α-pregnan-20-one
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Purity: >97.0%(HPLC)(qNMR)
Synonyms:
- Isopregnanolone
- 3-Deoxo-3β-hydroxy-5α-dihydroprogesterone
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 1G |
£85.00
|
1 | 30 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | H1839 |
| Purity / Analysis Method | >97.0%(HPLC)(qNMR) |
| Molecular Formula / Molecular Weight | C__2__1H__3__4O__2 = 318.50 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container | 1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 516-55-2 |
| Reaxys Registry Number | 2219963 |
| MDL Number | MFCD00064935 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 97.0 area% |
| Purity(qNMR) | min. 97.0 % |
| Melting point | 193.0 to 197.0 °C |
| Specific rotation | +93.0 to 99.0 deg(C=1, ethanol) |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 195 °C |
GHS
Related Laws:
| EC Number | 208-224-2 |
| RTECS# | TU4383200 |
Transport Information:
| HS Number | 2937230000 |
Application
3β-Hydroxy-5α-pregnan-20-one: An Endogenous Neuroactive Steroid
3β-Hydroxy-5α-pregnan-20-one (or isopregnanolone) and its stereoisomer, 5β-pregnan-3α-ol-20-one [P3084] are metabolites of the ovarian/adrenal steroid progesterone [P0478].1) These metabolites are endogenous neuroactive steroids that act as a positive allosteric modulator (PAM) of γ-aminobutyric acid A (GABAA) receptors with anesthetic, anxiolytic, and anti-convulsant effects.2,3) (The product is for research purpose only.)
References
- 1) Neurosteroids: Biosynthesis and Function of These Novel Neuromodulators
- 2) Neuroactive steroids: mechanisms of action and neuropsychopharmacological perspectives (a review)
- 3) Photoaffinity labeling identifies an intersubunit steroid-binding site in heteromeric GABA type A (GABAA) receptors
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