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Published TCIMAIL newest issue No.197
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CAS RN: 127-07-1 | Product Number: H0310
Hydroxyurea
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Purity: >97.0%(HPLC)(N)
Synonyms:
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 5G |
£17.00
|
6 | ≥40 |
|
| 25G |
£41.00
|
Contact Us | 17 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | H0310 |
| Purity / Analysis Method | >97.0%(HPLC)(N) |
| Molecular Formula / Molecular Weight | CH__4N__2O__2 = 76.06 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Hygroscopic |
| CAS RN | 127-07-1 |
| Reaxys Registry Number | 1741548 |
| PubChem Substance ID | 87570732 |
| SDBS (AIST Spectral DB) | 3920 |
| Merck Index (14) | 4848 |
| MDL Number | MFCD00007943 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 97.0 area% |
| Purity(with Total Nitrogen) | min. 97.0 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 140 °C |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H361 : Suspected of damaging fertility or the unborn child. H340 : May cause genetic defects. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up. |
Related Laws:
| EC Number | 204-821-7 |
| RTECS# | YT4900000 |
Transport Information:
| UN Number | UN2811 |
| Class | 6.1 |
| Packing Group | III |
| HS Number | 2928009090 |
Application
Adeno-associated virus vector transduction enhancer
Hydroxyurea increases transduction by adeno-associated virus (AAV) vectors.1)
References
- 1) DNA synthesis and topoisomerase inhibitors increase transduction by adeno-associated virus vectors
Application
Hydroxyurea (or hydroxycarbamide): A Ribonucleotide Reductase Inhibitor
Hydroxyurea (or hydroxycarbamide), a hydroxylated molecule of urea [U0077][U0073], is classified as an antitumor antimetabolite. Hydroxyurea inhibits deoxynucleotide and DNA synthesis by blocking the cellular enzyme ribonucleotide reductase, which is responsible for producing the deoxynucleotides required for DNA synthesis and repair, producing cell death in S phase (the phase of DNA synthesis). Recently, two effects of hydroxyurea have been reported: hydroxyurea increases the level of fetal hemoglobin, leading to a reduction in the incidence of vaso-occlusive crises in sickle cell anemia, and hydroxyurea inhibits human immunodeficiency virus-type 1 (HIV-1) DNA synthesis. (The product is for research purpose only.)
References
- Mechanism of action of hydroxyurea (a review)
- Inhibition of tumor cell ribonucleotide reductase by macrophage-derived nitric oxide
- Hydroxyurea as an inhibitor of human immunodeficiency virus-type 1 replication
- Pharmacokinetics and pharmacodynamics of hydroxyurea (a review)
- Nitric oxide production from hydroxyurea (a review)
- Colorimetric determination of hydroxyurea in human serum using high-performance liquid chromatography
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