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CAS RN: 498-02-2 | Product Number: H0261
4'-Hydroxy-3'-methoxyacetophenone
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Purity: >98.0%(GC)
Synonyms:
- Acetovanillone
- Apocynin
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 25G |
£44.00
|
3 | ≥100 |
|
| 100G |
£155.00
|
Contact Us | ≥100 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | H0261 |
| Purity / Analysis Method | >98.0%(GC) |
| Molecular Formula / Molecular Weight | C__9H__1__0O__3 = 166.18 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 498-02-2 |
| Reaxys Registry Number | 637373 |
| PubChem Substance ID | 87570688 |
| SDBS (AIST Spectral DB) | 6357 |
| Merck Index (14) | 741 |
| MDL Number | MFCD00008747 |
Specifications
| Appearance | White to Yellow to Orange powder to crystal |
| Purity(GC) | min. 98.0 % |
| Melting point | 113.0 to 117.0 °C |
| Solubility in Methanol | faint turbidity |
Properties (reference)
| Melting Point | 115 °C |
| Boiling Point | 300 °C |
| Maximum Absorption Wavelength | 383(MeOH) nm |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
Related Laws:
| EC Number | 207-854-5 |
| RTECS# | AM8800000 |
Transport Information:
| HS Number | 2914500090 |
Application
Apocynin: A Selective Inhibitor of NADPH Oxidase Activity
Apocynin, a methoxy-substituted catechol analog, is contained in the traditional medicinal plant Picrorhiza kurroa which has been used for the treatment of liver and heart problems. Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase is an enzyme that effectively reduces O2 to superoxide anion radical (O2–) by transferring one electron to oxygen from NADPH. The superoxide anion radical can be used by the immune system to kill bacteria and fungi. It has been reported that apocynin acts as an inhibitor of NADPH oxidase activity, and can decrease the production of superoxide anion radical from activated neutrophils and macrophages. The production of superoxide anion radical has also been shown to be associated with inflammation. Acutually, the anti-inflammatory activity of apocynin has been demonstrated in a variety of cell and animal models of inflammation. (A related compound: NADPH. 3Na Salt [T0521]) (The product is for research purpose only.)
References
- Characteristics of the inhibition of NADPH oxidase activation in neutrophils by apocynin, a methoxy-substituted catechol
- Apocynin: molecular aptitudes (a review)
PubMed Literature
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