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Published TCIMAIL newest issue No.197
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CAS RN: 1405-41-0 | Product Number: G0383
Gentamicin Sulfate
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Purity:
Synonyms:
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 1G |
£33.00
|
15 | ≥100 |
|
| 5G |
£124.00
|
2 | ≥100 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
Supplemental Product Information:
This product has not been tested and guaranteed for potency.
| Product Number | G0383 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Hygroscopic,Heat Sensitive |
| Packaging and Container | 1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 1405-41-0 |
| Related CAS RN | 1403-66-3 |
| PubChem Substance ID | 160871021 |
| MDL Number | MFCD00270181 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Total Nitrogen | 8.0 to 10.0 % |
| Specific rotation [a]20/D | +107.0 to +121.0 deg(C=1, H2O)(calcd.on anh.substance) |
| Water | max. 18.0 % |
Properties (reference)
| Specific Rotation | 115° (C=1,H2O) |
| Solubility (insoluble in) | Ether, Ethanol |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H317 : May cause an allergic skin reaction. H334 : May cause allergy or asthma symptoms or breathing difficulties if inhaled. |
| Precautionary Statements | P261 : Avoid breathing dust. P280 : Wear protective gloves. P284 : Wear respiratory protection. P342 + P311 : If experiencing respiratory symptoms: Call a POISON CENTER/doctor. P304 + P340 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. P333 + P313 : If skin irritation or rash occurs: Get medical advice/ attention. |
Related Laws:
| EC Number | 215-778-9 |
| RTECS# | LY2625000 |
Transport Information:
| HS Number | 2940000080 |
Application
Gentamicin: An Aminoglycoside Antibiotic with Potent Bactericidal Activities
Gentamicin, an aminoglycoside antibiotic, is isolated from Micromonospora purpurea, a genus of Gram-positive bacteria. It consists of a mixture of three isomers, gentamicin C1, gentamicin C1a and gentamicin C2. Gentamicin interacts with the 30S subunit of prokaryotic ribosomes, and then it inhibits bacterial growth by inhibiting protein synthesis. Gentamicin has activity against mostly Gram-negative bacteria including Pseudomonas, Proteus, Serratia, and the Gram-positive Staphylococcus. But, it is not used for Pneumococcus, Hemolytic streptococci, Bacteroides, Rickettsia and fungus. Gentamicin is widely used because of its potent bactericidal activities and less bacterial resistance, but it is well known to cause nephrotoxicity and hypacusis.
References
- The aminoglycosides
- Structural origins of gentamicin antibiotic action
- Impact of high-inoculum Staphylococcus aureus on the activities of nafcillin, vancomycin, linezolid, and daptomycin, alone and in combination with gentamicin, in an in vitro pharmacodynamic model
- Gentamicin-induced nephrotoxicity: Do we have a promising therapeutic approach to blunt it?
- Mesoporous SBA-15 HPLC evaluation for controlled gentamicin drug delivery
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