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Published TCIMAIL newest issue No.197
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CAS RN: 29113-33-5 | Product Number: E1123
Ethyl 4-Quinazolone-2-carboxylate
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Purity: >98.0%(T)(HPLC)
Synonyms:
- 4-Quinazolone-2-carboxylic Acid Ethyl Ester
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 1G |
£50.00
|
1 | 6 |
|
| 5G |
£235.00
|
1 | 3 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | E1123 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__1H__1__0N__2O__3 = 218.21 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 29113-33-5 |
| Reaxys Registry Number | 190186 |
| PubChem Substance ID | 354333138 |
| MDL Number | MFCD00051583 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
| Melting point | 190.0 to 194.0 °C |
Properties (reference)
| Melting Point | 192 °C |
| Maximum Absorption Wavelength | 297(MeOH) nm |
GHS
Related Laws:
Transport Information:
| HS Number | 2933998090 |
Application
A Synthetic Intermediate of Luotonin A, a Camptothecin Analogue
This product is widely used for the synthesis of “luotonin A” which is a camptothecin [C1495] analogue originally isolated from the Chinese herbal medicinal plant Peganum nigellastrum. As an antitumor agent, luotonin A demonstrates cytotoxic activity against mouse leukemia P388 cells.
References
- Product class 13: quinazolines (a review)
- Short and Efficient Total Synthesis of Luotonin A and 22-Hydroxyacuminatine Using A Common Cascade Strategy
- Total synthesis of luotonin A and 14-substituted analogues
- Weinreb amidation as the cornerstone of an improved synthetic route to A-ring-modified derivatives of luotonin A
PubMed Literature
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