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CAS RN: 125700-69-8 | Product Number: D3263
O-(3,4-Dihydro-4-oxo-1,2,3-benzotriazin-3-yl)-N,N,N',N'-tetramethyluronium Tetrafluoroborate
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Purity: >98.0%(HPLC)
Synonyms:
- TDBTU
- N,N,N',N'-Tetramethyl-O-(3,4-dihydro-4-oxo-1,2,3-benzotriazin-3-yl)uronium Tetrafluoroborate
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 5G |
£30.00
|
Contact Us | ≥40 |
|
| 25G |
£98.00
|
2 | ≥60 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | D3263 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__2H__1__6BF__4N__5O__2 = 349.10 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Light Sensitive,Moisture Sensitive,Heat Sensitive |
| CAS RN | 125700-69-8 |
| PubChem Substance ID | 160870982 |
| MDL Number | MFCD00077730 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
Properties (reference)
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H302 : Harmful if swallowed. H314 : Causes severe skin burns and eye damage. |
| Precautionary Statements | P260 : Do not breathe dust. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. P303 + P361 + P353 : IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water. P301 + P330 + P331 : IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P304 + P340 + P310 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Immediately call a POISON CENTER/doctor. P305 + P351 + P338 + P310 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER/doctor. |
Related Laws:
Transport Information:
| UN Number | UN1759 |
| Class | 8 |
| Packing Group | III |
| HS Number | 2933998090 |
Application
Condensing Agent
Experimental procedure:
To a stirred solution of 1 (60 mg, 0.133 mmol), DIEA (19.4 mg, 0.15 mmol) in anhydrous DMF (0.5 mL) is added TDBTU (51.1 mg, 0.145 mmol), and the reaction mixture is stirred at room temperature for 2 h. A solution of spermine (5.6 mg, 0.028 mmol) and DIEA (0.074 g, 0.57 mmol) in anhydrous DMF (0.2 mL) is then added dropwise and the resulting solution stirred at 55 °C for 6 h. The mixture is then concentrated under reduced pressure, and the resulting solid is dissolved in CH3OH (2 mL). Subsequent precipitation, by addition to an aqueous solution that is saturated with NaHCO3, and preparative thin-layer chromatography (SiO2, CHCl3:CH3OH = 15:1) affords 2 (42.9 mg, 79%).
To a stirred solution of 1 (60 mg, 0.133 mmol), DIEA (19.4 mg, 0.15 mmol) in anhydrous DMF (0.5 mL) is added TDBTU (51.1 mg, 0.145 mmol), and the reaction mixture is stirred at room temperature for 2 h. A solution of spermine (5.6 mg, 0.028 mmol) and DIEA (0.074 g, 0.57 mmol) in anhydrous DMF (0.2 mL) is then added dropwise and the resulting solution stirred at 55 °C for 6 h. The mixture is then concentrated under reduced pressure, and the resulting solid is dissolved in CH3OH (2 mL). Subsequent precipitation, by addition to an aqueous solution that is saturated with NaHCO3, and preparative thin-layer chromatography (SiO2, CHCl3:CH3OH = 15:1) affords 2 (42.9 mg, 79%).
References
- 1)New coupling reagents in peptide chemistry
- 2)Ion Conductors Derived from Cholic Acid and Spermine: Importance of Facial Hydrophilicity on Na+ Transport and Membrane Selectivity
- 3)A Molecular Umbrella Approach to the Intracellular Delivery of Small Interfering RNA
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