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Published TCIMAIL newest issue No.197
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CAS RN: 35607-66-0 | Product Number: C3598
Cefoxitin
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Purity: >98.0%(HPLC)
Synonyms:
- (6R,7S)-3-[(Carbamoyloxy)methyl]-7-methoxy-8-oxo-7-[2-(thiophen-2-yl)acetamido]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 1G |
£56.00
|
2 | ≥40 |
|
| 5G |
£177.00
|
1 | 11 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
Supplemental Product Information:
This product has not been tested for potency and is guaranteed for chemical purity.
| Product Number | C3598 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__6H__1__7N__3O__7S__2 = 427.45 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (<0°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container | 1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 35607-66-0 |
| Reaxys Registry Number | 4216947 |
| PubChem Substance ID | 468591185 |
| Merck Index (14) | 1936 |
| MDL Number | MFCD00072014 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 95.0 % |
Properties (reference)
| Melting Point | 127 °C(dec.) |
| Solubility (soluble in) | Dimethylformamide |
| Solubility (insoluble in) | Ether, Chloroform |
GHS
Related Laws:
| EC Number | 252-641-2 |
| RTECS# | XI0386500 |
Transport Information:
| HS Number | 2941900000 |
Application
Cefoxitin: A Second Generation Cephem Antibiotic against beta-Lactamase
Cefoxitin and its sodium salt [C3602] are semi-synthetic antibiotic that are derived from cephamycin C which is produced by Streptomyces lactamdurans. Cefoxitins have bactericidal activity against a wide range of Gram-negative and Gram-positive bacteria including aerobes and anaerobes.1-3) Cefoxitins are second generation cephem antibiotics which act by inhibition bacterial cell wall synthesis. Due to the presence of a 7-α methoxy group in the β-lactam ring, cefoxitins exhibit a high degree of stability in the presence of beta-lactamases. In addition, cefoxitin disk diffusion method has been used for the tests for routine detection of all classes of MRSA.4,5)
References
- 1) Cefoxitin, a semi-synthetic cephamycin: a microbiological overview (a review)
- 2) Cefoxitin and cephamycins: microbiological studies (a review)
- 3) Cefoxitin: a review of its antibacterial activity, pharmacological properties and therapeutic use
- 4) Evaluation of three techniques for detection of low-level methicillin-resistant Staphylococcus aureus (MRSA): a disk diffusion method with cefoxitin and moxalactam, the Vitek 2 system, and the MRSA-screen latex agglutination test
- 5) Results of disk diffusion testing with cefoxitin correlate with presence of mecA in Staphylococcus spp.
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