Published TCIMAIL newest issue No.196
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CAS RN: 5786-21-0 | Product Number: C2547
Clozapine
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Purity: >98.0%(GC)(T)
Synonyms:
- 8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 100MG |
£31.00
|
4 | ≥100 |
|
| 1G |
£196.00
|
4 | ≥100 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | C2547 |
| Purity / Analysis Method | >98.0%(GC)(T) |
| Molecular Formula / Molecular Weight | C__1__8H__1__9ClN__4 = 326.83 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 5786-21-0 |
| Reaxys Registry Number | 764984 |
| PubChem Substance ID | 135726987 |
| Merck Index (14) | 2423 |
| MDL Number | MFCD00153785 |
Specifications
| Appearance | Light yellow to Amber to Dark green powder to crystal |
| Purity(GC) | min. 98.0 % |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 183.0 to 187.0 °C |
Properties (reference)
| Melting Point | 185 °C |
| Solubility in water | Insoluble |
| Solubility (soluble in) | Methanol, Acetone, Chloroform |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H301 : Toxic if swallowed. H315 : Causes skin irritation. H319 : Causes serious eye irritation. H413 : May cause long lasting harmful effects to aquatic life. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P273 : Avoid release to the environment. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. |
Related Laws:
| EC Number | 227-313-7 |
| RTECS# | HP1750000 |
Transport Information:
| UN Number | UN2811 |
| Class | 6.1 |
| Packing Group | III |
| HS Number | 2933998090 |
Application
Clozapine: A Dibenzodiazepine Agent with Effects on Various Receptors
Clozapine is a dibenzodiazepine “atypical” antipsychotic agent. The precise mechanism of actions is not fully understood. However, it has been reported that the therapeutic efficacy of clozapine is mediated through antagonism of the serotonin type 2A (5-HT2A) receptors. Clozapine also act as an antagonist at adrenergic, cholinergic, histaminergic, dopaminergic and serotonergic receptors. (The product is for research purpose only.)
References
- Clinical studies on the mechanism of action of clozapine: the dopamine-serotonin hypothesis of schizophrenia (a review)
- Molecular cloning and characterization of a novel dopamine receptor (D3) as a target for neuroleptics
- Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine
- New insights into the biology of schizophrenia through the mechanism of action of clozapine (a review)
- Metabolism and bioactivation of clozapine by human liver in vitro
- Quantitative determination of forty-eight antidepressants and antipsychotics in human serum by HPLC tandem mass spectrometry: A multi-level, single-sample approach
Application
HDAC2 may be a New Target for Schizophrenia Treatment
Reference
- HDAC2 regulates atypical antipsychotic responses through the modulation of mGlu2 promoter activity
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