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CAS RN: 4291-63-8 | Product Number: C2499
Cladribine
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Purity: >98.0%(HPLC)
Synonyms:
- 2-Chloro-2'-deoxyadenosine
- 2-Chloro-9-(2-deoxy-β-D-arabinofuranosyl)adenine
- CdA
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 50MG |
£39.00
|
2 | ≥40 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | C2499 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__0H__1__2ClN__5O__3 = 285.69 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container | 50MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 4291-63-8 |
| Reaxys Registry Number | 624220 |
| PubChem Substance ID | 160871152 |
| Merck Index (14) | 2337 |
| MDL Number | MFCD00153939 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
Properties (reference)
| Melting Point | 220 °C |
| Maximum Absorption Wavelength | 265(EtOH aq.) nm |
GHS
Related Laws:
| RTECS# | AU7357560 |
Transport Information:
| HS Number | 2934999090 |
Application
Studies on Chronic Lymphocytic Leukemia Cells
References
- Deoxyadenosine analogs induce programmed cell death in chronic lymphocytic leukemia cells by damaging the DNA and by directly affecting the mitochondria
- D. Genini, S. Adachi, Q. Chao, D. W. Rose, C. J. Carrera, H. B. Cottam, D. A. Carson, L. M. Leoni, Blood 2000, 96, 3537.
- Induction of apoptotic cell death in chronic lymphocytic leukemia by 2-chloro-2'-deoxyadenosine and 9-β-D-arabinosyl-2-fluoroadenine
- L. E. Robertson, S. Chubb, R. E. Meyn, M. Story, R. Ford, W. N. Hittelman, W. Plunkett, Blood 1993, 81, 143.
- Specific toxicity of 2-chlorodeoxyadenosine toward resting and proliferating human lymphocytes
- D. A. Carson, D. B. Wasson, R. Taetle, A. Yu, Blood 1983, 62, 737.
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