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CAS RN: 627810-06-4 | Product Number: B6654
BMVC
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Purity: >95.0%(HPLC)(qNMR)
Synonyms:
- 3,6-Bis[2-(1-methylpyridin-1-ium-4-yl)ethenyl]-9H-carbazole Diiodide
- 4,4′-(9H-Carbazole-3,6-diyldi-2,1-ethenediyl)bis(1-methylpyridinium) Diiodide
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 5MG |
£171.00
|
Contact Us | ≥100 |
|
| 25MG |
£684.00
|
Contact Us | ≥100 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | B6654 |
| Purity / Analysis Method | >95.0%(HPLC)(qNMR) |
| Molecular Formula / Molecular Weight | C__2__8H__2__5I__2N__3 = 657.34 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (-20°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Light Sensitive,Air Sensitive,Moisture Sensitive,Heat Sensitive |
| CAS RN | 627810-06-4 |
| Reaxys Registry Number | 21918735 |
| MDL Number | MFCD32671332 |
Specifications
| Appearance | Light yellow to Brown powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Purity(qNMR) | min. 95.0 % |
| NMR | confirm to structure |
Properties (reference)
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
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Application
BMVC: A Fluorescent G4 Ligand with Telomerase Inhibitory Activity
Guanine quadruplexes (G4s) are non-Watson-Crick four-stranded nucleic acid structures held together by noncanonical G-G base tetrads. Recent studies indicate their existence in vivo and their involvement in various biological processes.1) BMVC, a fluorescent G4 ligand, can be used not only as a fluorescent probe to image endogenous and exogenous G4 in living cells,2,3) but also as a reagent to arrest cancer growth by inhibiting telomerase activity and regulating gene expression.3-5) Thus, BMVC is an invaluable reagent for detecting G4 in cells, investigating the biological function of G4, and guiding the development of anti-cancer agents.5,6) (The product is for research use only.)
References
- 1) G-quadruplex interacting small molecules and drugs: from bench toward bedside (a review)
- 2) Detection of quadruplex DNA structures in human telomeres by a fluorescent carbazole derivative
- 3) A novel carbazole derivative, BMVC: A potential antitumor agent and fluorescence marker of cancer cells
- 4) G-Quadruplex Stabilizer 3,6-Bis(1-Methyl-4-Vinylpyridinium)Carbazole Diiodide Induces Accelerated Senescence and Inhibits Tumorigenic Properties in Cancer Cells
- 5) Direct evidence of mitochondrial G-quadruplex DNA by using fluorescent anti-cancer agents
- 6) A Fluorescent Anti-Cancer Agent, 3,6-bis(1-methyl-4-vinylpyridinium) Carbazole Diiodide, Stains G-Quadruplexes in Cells and Inhibits Tumor Growth (a review)
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