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Published TCIMAIL newest issue No.197
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CAS RN: 3562-84-3 | Product Number: B4099
Benzbromarone
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Purity: >98.0%(GC)(T)
Synonyms:
- 3-(3,5-Dibromo-4-hydroxybenzoyl)-2-ethylbenzofuran
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 1G |
£31.00
|
1 | ≥40 |
|
| 5G |
£106.00
|
1 | ≥40 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | B4099 |
| Purity / Analysis Method | >98.0%(GC)(T) |
| Molecular Formula / Molecular Weight | C__1__7H__1__2Br__2O__3 = 424.09 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Packaging and Container | 1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 3562-84-3 |
| Reaxys Registry Number | 273668 |
| PubChem Substance ID | 253661712 |
| Merck Index (14) | 1065 |
| MDL Number | MFCD00078962 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(GC) | min. 98.0 % |
| Purity(Neutralization titration) | min. 98.0 % |
| Melting point | 150.0 to 154.0 °C |
Properties (reference)
| Melting Point | 152 °C |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H301 : Toxic if swallowed. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
Related Laws:
| EC Number | 222-630-7 |
| RTECS# | OB1804200 |
Transport Information:
| UN Number | UN2811 |
| Class | 6.1 |
| Packing Group | III |
| HS Number | 2932990090 |
Application
Benzbromarone: An Inhibitor of Xanthine Oxidase (XO) and Cytochrome P450 2C9 (CYP2C9)
Benzbromarone is a benzofuran derivative and non-competitive inhibitor of xanthine oxidase (XO). Benzbromarone reduces the production of uric acid, increases the excretion of uric acid through the kidneys and used in the treatment of gout. It is a very potent inhibitor of cytochrome P450 2C9 (CYP2C9). (The product is for research purpose only.)
References
- Benzbromarone: a review of its pharmacological properties and therapeutic use in gout and hyperuricemia
- Potentiation of anticoagulant effect of warfarin caused by enantioselective metabolic inhibition by the uricosuric agent benzbromarone
- Mechanisms of benzarone and benzbromarone-induced hepatic toxicity
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