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CAS RN: 13528-93-3 | Product Number: B1688
1,2-Bis(chlorodimethylsilyl)ethane [Protecting Reagent for Primary Amines]
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![1,2-Bis(chlorodimethylsilyl)ethane [Protecting Reagent for Primary Amines]](/_ui/responsive/theme-tci/images/missing_product_zoom.jpg "1,2-Bis(chlorodimethylsilyl)ethane [Protecting Reagent for Primary Amines]")
Purity: >95.0%(GC)
Synonyms:
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 5G |
£28.00
|
Contact Us | 2 |
|
| 25G |
£130.00
|
1 | 1 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | B1688 |
| Purity / Analysis Method | >95.0%(GC) |
| Molecular Formula / Molecular Weight | C__6H__1__6Cl__2Si__2 = 215.26 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Moisture Sensitive |
| CAS RN | 13528-93-3 |
| Reaxys Registry Number | 1920141 |
| PubChem Substance ID | 87564589 |
| SDBS (AIST Spectral DB) | 19610 |
| MDL Number | MFCD00000505 |
Specifications
| Appearance | White or Colorless to Almost white or Almost colorless powder to lump to clear liquid |
| Purity(GC) | min. 95.0 % |
Properties (reference)
| Melting Point | 36 °C |
| Boiling Point | 198 °C |
| Flash point | 65 °C |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H314 : Causes severe skin burns and eye damage. H290 : May be corrosive to metals. |
| Precautionary Statements | P260 : Do not breathe dust or mist. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P303 + P361 + P353 : IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water. P301 + P330 + P331 : IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P304 + P340 + P310 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Immediately call a POISON CENTER/doctor. P305 + P351 + P338 + P310 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER/doctor. |
Related Laws:
| EC Number | 236-871-0 |
Transport Information:
| UN Number | UN2987 |
| Class | 8 |
| Packing Group | II |
| HS Number | 2931900090 |
Application
Protecting Silicon Reagent for Primary Amines
Typical Procedure (Protection of ethyl glycinate)1):
A solution of 1,2-bis(chlorodimethylsilyl)ethane (1.8 g, 8 mmol) in anhydrous dichloromethane (3 mL) is added via a syringe to a stirred solution of ethyl glycinate (0.75 g, 8 mmol) in dichloromethane (5 mL) containing triethylamine (2 eq.). The mixture is stirred, under argon at room temperature for 2 hours and then poured into aqueous sodium dihydrogen phosphate (5 mL). The pure product is obtained by distillation (1.86 g, 92%), bp. 80-82 °C (0.25 mmHg).
A solution of 1,2-bis(chlorodimethylsilyl)ethane (1.8 g, 8 mmol) in anhydrous dichloromethane (3 mL) is added via a syringe to a stirred solution of ethyl glycinate (0.75 g, 8 mmol) in dichloromethane (5 mL) containing triethylamine (2 eq.). The mixture is stirred, under argon at room temperature for 2 hours and then poured into aqueous sodium dihydrogen phosphate (5 mL). The pure product is obtained by distillation (1.86 g, 92%), bp. 80-82 °C (0.25 mmHg).
References
- 1)S. Djuric, J. Venit, P. Magnus, Tetrahedron Lett. 1981, 22, 1787.
- 2)S. Kojima, K. Akiba, Yuki Gosei Kagaku Kyokaishi (J. Synth. Org. Chem., Jpn.) 1990, 48, 1040.
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