1
Published TCIMAIL newest issue No.197
Maximum quantity allowed is 999
Merci de sélectionner la quantité
Glycogen Synthase Kinase 3 (GSK3) Inhibitor: SB 216763
No.179(November 2018)
SB 216763 (1) is a potent and selective cell permeable glycogen synthase kinase 3 (GSK3) inhibitor.1) The inhibitory mechanism is ATP-competitive. The Ki and IC50 of 1 to GSK-3α are 9.10 nM and 34.3 nM, respectively.
1 can maintain mESCs in a pluripotent state in the absence of exogenous leukemia inhibitory factor (LIF) when cultured on mouse embryonic fibrobrasts (MEFs).2) 1 promotes the generation of hematopoietic stem cells (HSCs) in aorta-gonad-mesonephros (AGM) explants.3)This product is for research purpose only.
1 can maintain mESCs in a pluripotent state in the absence of exogenous leukemia inhibitory factor (LIF) when cultured on mouse embryonic fibrobrasts (MEFs).2) 1 promotes the generation of hematopoietic stem cells (HSCs) in aorta-gonad-mesonephros (AGM) explants.3)
References
- 1)Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription
- 2)Glycogen synthase kinase 3 (GSK3) inhibitor, SB-216763, promotes pluripotency in mouse embryonic stem cells
- 3)Hematopoietic stem cell development requires transient Wnt/β-catenin activity
The prices are subject to change without notice. Please confirm the newest price by our online catalog before placing an order.
In addition, sales products changes with areas. Please understand that a product is not available when the product details page is not displayed.
In addition, sales products changes with areas. Please understand that a product is not available when the product details page is not displayed.