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Published TCIMAIL newest issue No.197
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CAS RN: 52-24-4 | Product Number: T4184
Thiotepa
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Purity: >95.0%(HPLC)
Synonyms:
- Thio-TEPA
- Tri(aziridin-1-yl)phosphine Sulfide
- 1-[Bis(1-aziridinyl)phosphorothioyl]aziridine
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 250MG |
€335.00
|
Contact Us | 17 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | T4184 |
| Purity / Analysis Method | >95.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__6H__1__2N__3PS = 189.22 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| CAS RN | 52-24-4 |
| Reaxys Registry Number | 145978 |
| MDL Number | MFCD00145452 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Melting point | 52.0 to 56.0 °C |
| Water | max. 2.0 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 54 °C |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H300 : Fatal if swallowed. H360 : May damage fertility or the unborn child. H371 : May cause damage to organs. H372 : Causes damage to organs through prolonged or repeated exposure. H340 : May cause genetic defects. H350 : May cause cancer. |
| Precautionary Statements | P260 : Do not breathe dust/ fume/ gas/ mist/ vapours/ spray. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. P308 + P311 : IF exposed or concerned: Call a POISON CENTER/doctor. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. |
Related Laws:
| EC Number | 200-135-7 |
| RTECS# | SZ2975000 |
Transport Information:
| UN Number | UN2811 |
| Class | 6.1 |
| Packing Group | II |
| HS Number | 2933998090 |
Application
Thiotepa: An Alkylating Cytotoxic Agent with a Broad Spectrum of Antitumor Activity
Thiotepa (ThioTEPA) is a trifunctional alkylating cytotoxic agent with a broad spectrum of antitumor activity. It is thought to inhibit tumor growth by inhibiting DNA synthesis.1) The major DNA bond cleavages are initiated by alkylation of guanine and adenine at the N-7 position, which breaks the bond between the purine base and the sugar, releasing alkylated guanines and adenines.2) (The product is for research purpose only.)
References
- 1) Chemistry, pharmacology and pharmacokinetics of N,N',N" - triethylenethiophosphoramide triethylenethiophosphoramide (ThioTEPA) (a review)
- 2) Density Functional Theory Investigation of the Binding of ThioTEPA to Purine Bases: Thermodynamics and Bond Evolution Theory Analysis
Product Documents (Note: Some products will not have analytical charts available.)
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