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CAS RN: 144481-98-1 | Product Number: L0296
Landiolol Hydrochloride
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Purity: >98.0%(T)(HPLC)
Synonyms:
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 50MG |
€90.00
|
Contact Us | 1 |
|
| 250MG |
€301.00
|
1 | 10 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | L0296 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__2__5H__3__9N__3O__8·HCl = 546.06 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Hygroscopic |
| CAS RN | 144481-98-1 |
| Related CAS RN | 133242-30-5 |
| Reaxys Registry Number | 5845039 |
| PubChem Substance ID | 354334831 |
| MDL Number | MFCD00911043 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 124.0 to 128.0 °C |
Properties (reference)
| Melting Point | 126 °C |
| Solubility (soluble in) | Dimethylformamide |
| Solubility (slightly sol. in) | Ethanol |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
Related Laws:
| RTECS# | DA8346700 |
Transport Information:
| HS Number | 2934999090 |
Application
Landiolol Hydrochloride: A Highly Cardioselective, Short-Acting Adrenergic β1-Selective Antagonist
Landiolol hydrochloride (ONO-1101) is a highly cardioselective, short-acting adrenergic β1-selective antagonist (blocker). Landiolol reduces heart rate by selectively blocking β1 receptors located chiefly in the heart. It is reported that landiolol has 8-fold greater cardioselectivity than esmolol [E1106] in vitro. Landiolol is a short-acting agent since the ester group of landiolol is rapidly hydrolyzed to an inactivate metabolite by esterases in plasma and liver. Landiolol hydrochloride is used for the treatment of tachyarrhythmia and better control of heart rate in surgery. (The product is for research purpose only.)
References
- Development of a highly cardioselective ultra short-acting β-blocker, ONO-1101
- Electrophysiologic, cardiohemodynamic and β-blocking actions of a new ultra-short-acting β-blocker, ONO-1101, assessed by the in vivo canine model in comparison with esmolol
- Landiolol: A Review of its use in Intraoperative and Postoperative Tachyarrhythmias
- Detection of landiolol using high-performance liquid chromatography/fluorescence: A blood esterase-sensitive ultra-short-acting β1-receptor antagonist
- Validation of HPLC-UV methods for quantitatively determining landiolol and its major metabolite in human blood
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