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Published TCIMAIL newest issue No.197
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CAS RN: 51-21-8 | Product Number: F0151
5-Fluorouracil
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Purity: >99.0%(T)(HPLC)
Synonyms:
- 5-FU
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 5G |
27,00 €
|
2 | 37 |
|
| 25G |
89,00 €
|
3 | ≥40 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | F0151 |
| Purity / Analysis Method | >99.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__4H__3FN__2O__2 = 130.08 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 51-21-8 |
| Reaxys Registry Number | 127172 |
| PubChem Substance ID | 87569939 |
| SDBS (AIST Spectral DB) | 3722 |
| Merck Index (14) | 4181 |
| MDL Number | MFCD00006018 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 99.0 area% |
| Purity(Neutralization titration) | min. 99.0 % |
| Solubility in hot Water | almost transparency |
Properties (reference)
| Melting Point | 283 °C(dec.) |
| Solubility in water | Slightly soluble |
| Solubility (soluble in) | Dimethylformamide |
| Solubility (slightly sol. in) | Methanol |
| Solubility (insoluble in) | Chloroform, Benzene, Ether |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H301 : Toxic if swallowed. H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. |
Related Laws:
| EC Number | 200-085-6 |
| RTECS# | YR0350000 |
Transport Information:
| UN Number | UN2811 |
| Class | 6.1 |
| Packing Group | III |
| HS Number | 2933599590 |
Application
Quorum sensing research / Biofilm research
References
- 5-Fluorouracil blocks quorum-sensing of biofilm-embedded methicillin-resistant Staphylococcus aureus in mice
- The Role of Drug Repurposing in the Development of Novel Antimicrobial Drugs: Non-Antibiotic Pharmacological Agents as Quorum Sensing-Inhibitors
- 5-Fluorouracil reduces biofilm formation in Escherichia coli K-12 through global regulator AriR as an antivirulence compound
- Uracil influences quorum sensing and biofilm formation in Pseudomonas aeruginosa and fluorouracil is an antagonist
Application
5-Fluorouracil (5-FU): An Antitumor Antimetabolite with Activity against Numerous Types of Neoplasms
5-Fluorouracil (5-FU) is an antitumor antimetabolite with activity against numerous types of neoplasms. Further, many prodrugs of 5-FU have been developed to increased plasma and tumor 5-FU concentrations and to improve the cytotoxicity, such as capecitabine [C2878], doxifluridine [D3579], carmofur [C2663], tegaful [F0635], UFT (tegafur and uracil [U0013]) and S-1 (tegafur, gimeracil [C2243] and potassium oxonate [O0164]). (The product is for research purpose only.)
References
- Fluorouracil: biochemistry and pharmacology (a review)
- 5-Fluorouracil: mechanisms of action and clinical strategies (a review)
- Induction of thymidylate synthase as a 5-fluorouracil resistance mechanism (a review)
- The prodrugs of 5-fluorouracil (a review)
- Determination of 5-fluorouracil in environmental samples by solid-phase extraction and high-performance liquid chromatography with ultraviolet detection
- A review of analytical methods for the determination of 5-fluorouracil in biological matrices
Application
Reagent for gastropathy (gastric mucosal injury) model
References
- 16-16 dimethyl prostaglandin E2 reduces 5-fluorouracil-induced and mitomycin C-induced gastric mucosal injury in the dog
- Effects of acid antisecretory drugs on mucus barrier of the rat against 5-fluorouracil-induced gastrointestinal mucositis
Application
Reagent for nausea or vomiting model
Reference
- The anti-cancer drug-induced pica in rats is related to their clinical emetogenic potential
PubMed Literature
Articles/Brochures
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