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Published TCIMAIL newest issue No.197
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CAS RN: 183232-66-8 | Product Number: A3151
AM 251
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Purity: >97.0%(HPLC)
Synonyms:
- 1-(2,4-Dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 10MG |
155,00 €
|
4 | Contact Us |
|
| 50MG |
507,00 €
|
1 | 28 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | A3151 |
| Purity / Analysis Method | >97.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__2H__2__1Cl__2IN__4O = 555.24 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (<0°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 183232-66-8 |
| Reaxys Registry Number | 7780333 |
| PubChem Substance ID | 354335179 |
| MDL Number | MFCD01861181 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 97.0 area% |
| Elemental analysis(Nitrogen) | 9.60 to 10.60 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 196 °C |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
Related Laws:
Transport Information:
| HS Number | 2933399990 |
Application
AM-251: A Cannabinoid CB1 Receptors (CB1Rs) Antagonist
AM-251 is a cannabinoid CB1 receptors (CB1Rs) antagonist. In areas of the central nervous system (CNS), CB1 receptors have been implicated in regulation of mood and food intake. Reportedly, CB1 agonists increase food intake while CB1 receptor antagonists reduce food intake. AM-251, a CB1 receptor antagonist, have been shown to antidepressant-like and anorectic effects in rats. (The product is for research purpose only.)
References
- Structure-Activity Relationships of Pyrazole Derivatives as Cannabinoid Receptor Antagonists
- Antiobesity effects of chronic cannabinoid CB1 receptor antagonist treatment in diet-induced obese mice
- Antidepressant-like and anorectic effects of the cannabinoid CB1 receptor inverse agonist AM251 in mice
- Inverse agonism and neutral antagonism at cannabinoid CB1 receptors (a review)
- Pharmacological actions of cannabinoids (a review)
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