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Published TCIMAIL newest issue No.198
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Tumor-associated Antigens
Carbohydrates play important roles in various biological functions such as cell recognition, cell adhesion, intercellular and intracellular signaling, and embryonic development. Cellular glycosylation profiles significantly change during carcinogenesis. These cellular carbohydrate structures are known as tumor-associated carbohydrate antigens, and they are considered promising targets for immunotherapy as well as developing vaccines and therapeutic antibodies. TCI supports the research in this field with various tools.
Products
Sialyl Lewis X/CD15s-related Products
Lewis X/CD15-related Products
Sialyl Lewis A-related Products
Lewis Y/ CD174-related Products
GD2-related Products
GD3/CD60a-related Products
GM2-related Products
GM3-related Products
Forssman Antigen-related Products
Gb3/CD77-related Products
SSEA-3-related Products
Globo H-related Products
The glycomoiety structure of proteins and lipids changes in cancerous cells. For example, N-acetylglucosaminyltransferase V (GnT-V) is expressed at a very low level in normal cells, but is abundant in cancer cells. Due to such changes in the expression levels of glycosyltransferases, the synthesized oligosaccharide chains vary based on the type of cancer cells, and can be used as diagnostic markers.
Cancer cell-specific oligosaccharides play important roles, such as immortalization of cancer cell, cell adhesion / metastases, and abnormal growth. Such cancer cell-specific oligosaccharides are good targets for drug discovery, and these oligosaccharides are being used to develop therapeutic targets, vaccine preparations (using cancer antigens), inhibitors of carbohydrate synthesis, galectins, and selectins, antibody-based drugs targeting oligosaccharide antigens, and chimeric antigen receptor gene modified T cells (CAR-T).
References
- 1) Glycobiomarker, Fucosylated Short-Form Secretogranin III Levels Are Increased in Serum of Patients with Small Cell Lung Carcinoma
- 2) Glycans in cancer and inflammation — potential for therapeutics and diagnostics
- 3) Tumour-associated carbohydrate antigens in breast cancer
- 4) Expression of Lewisa, Sialyl Lewisa, Lewisx, Sialyl Lewisx, Antigens as Prognostic Factors in Patients with Colorectal Cancer
- 5) WHO classification of tumours of the haematopoietic and lymphoid tissues
- WHO classification of tumours of the haematopoietic and lymphoid tissues, 4th ed., ed. by S. H. Swerdlow, E. Campo, N. L. Harris, et al., IARC Press, Lyon, 2000, pp. 157-334.
- WHO classification of tumours of the haematopoietic and lymphoid tissues, 4th ed., ed. by S. H. Swerdlow, E. Campo, N. L. Harris, et al., IARC Press, Lyon, 2000, pp. 157-334.
- 6) The sweet and sour of cancer: glycans as novel therapeutic targets
- 7) Structures Common to Different Glycans.
- 8) Ganglioside GM2 as a human tumor antigen (OFA-I-1)
- 9) Molecular cloning of globotriaosylceramide/CD77 synthase, a glycosyltransferase that initiates the synthesis of globo series glycosphingolipids
- 10) Shiga toxin receptor Gb3Cer/CD77: tumor-association and promising therapeutic target in pancreas and colon cancer
- 11) Cancer-Associated Glycosphingolipid Antigens: Their Structure, Organization, and Function
- 12) Detection of ganglioside GD2 in tumor tissues and sera of neuroblastoma patients.
- 13) Ganglioside G(D2) in small cell lung cancer cell lines: enhancement of cell proliferation and mediation of apoptosis.
- 14) Disialoganglioside GD2 as a therapeutic target for human diseases.
HSA-Oligosaccaride Conjugates
Useful tools for evaluating carbohydrate-binding molecules
These are useful tools for evaluating carbohydrate-binding molecules, including antibodies.
The recombinant HSA produced in plants does not contain animal-derived components and cannot be contaminated with virus. Additionally, it has the same structure, characteristics, and biological activity as natural HSA. Several sugar-conjugates are available, and it is also possible to manufacture the sugar-conjugates according to customer specifications. For more details on the products and contracts, please contact us.
