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CAS RN: 171596-29-5 | Product Number: T4029
Tadalafil
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Purity: >98.0%(T)(HPLC)
Synonyms:
- (6R,12aR)-6-(1,3-Benzodioxol-5-yl)-2-methyl-2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 25G |
€163.00
|
2 | 5 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | T4029 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__2__2H__1__9N__3O__4 = 389.41 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| CAS RN | 171596-29-5 |
| Reaxys Registry Number | 9589181 |
| MDL Number | MFCD07771966 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Volumetric Analysis) | min. 98.0 % |
| Specific rotation | +70.0 to +76.0 deg(C=1, CHCl3) |
| NMR | confirm to structure |
Properties (reference)
| Solubility in water | Insoluble |
| Solubility (soluble in) | Dimethylformamide |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
Related Laws:
| RTECS# | UQ4431050 |
Transport Information:
| HS Number | 2934999090 |
Application
Tadalafil: A cGMP-Specific PDE5 Inhibitor
Tadalafil is a selective inhibitor of cyclic guanosine monophosphate (cGMP) specific phosphodiesterase type 5 (PDE5) which is the predominant PDE isoenzyme in human corpora cavernosa, as with sildenafil [S0986, Citrate].1,2) Although its chemical structure is significantly different from sildenafil, tadalafil shows significant potency for PDE5 inhibition. Current data suggest that PDE5 modulates distinct regulatory pathways in the cell. This property therefore offer the opportunity for selectively targeting specific PDE5 for treatment of specific disease states.2) In fact, tadalafil is widely used also for the treatment of pulmonary arterial hypertension (PAH) which is a progressive disease that ultimately causes right heart failure and death.3) In addition, tadalafil has been reported in some cases to be contained in adulterated food supplements, and methods for its detection are being developed.4,5) (The product is for research purpose only.)
References
- 1) Tadalafil (a review)
- 2) cGMP-dependent protein kinases and cGMP phosphodiesterases in nitric oxide and cGMP action
- 3) Phosphodiesterase type 5 inhibitors in pulmonary arterial hypertension
- 4) Analysis of undeclared synthetic phosphodiesterase-5 inhibitors in dietary supplements and herbal matrices by LC-ESI-MS and LC-UV
- 5) Towards a decade of detecting new analogues of sildenafil, tadalafil and vardenafil in food supplements: A history, analytical aspects and health risks (a review)
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