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CAS RN: 440-17-5 | Product Number: T2849
Trifluoperazine Dihydrochloride
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Purity: >98.0%(T)(HPLC)
Synonyms:
- 10-[3-(4-Methylpiperazin-1-yl)propyl]-2-(trifluoromethyl)phenothiazine Dihydrochloride
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 5G |
€68.00
|
Contact Us | ≥40 |
|
| 25G |
€216.00
|
1 | 7 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | T2849 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__2__1H__2__4F__3N__3S·2HCl = 480.42 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (<0°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 440-17-5 |
| Related CAS RN | 117-89-5&605-75-4 |
| Reaxys Registry Number | 3820024 |
| PubChem Substance ID | 160871333 |
| Merck Index (14) | 9680 |
| MDL Number | MFCD00012656 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 %(calcd.on dried substance) |
| Drying loss | max. 3.0 % |
Properties (reference)
| Melting Point | 293 °C(dec.) |
| Maximum Absorption Wavelength | 312(MeOH) nm |
| Solubility (insoluble in) | Ether, Benzene |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. H361 : Suspected of damaging fertility or the unborn child. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. |
Related Laws:
| EC Number | 207-123-0 |
| RTECS# | SP1750000 |
Transport Information:
| HS Number | 2934309090 |
Application
Trifluoperazine Dihydrochloride: A Phenothiazine Dopamine D2 Receptor Antagonist
Trifluoperazine dihydrochloride is a phenothiazine dopamine receptor antagonist which has been extensively used for its antipsychotic properties. However, recently, there is good evidence to suggest that, in common with other phenothiazine agents, trifluoperazine has important antibacterial activity. (The product is for research purpose only.)
References
- Dopamine receptor binding predicts clinical and pharmacological potencies of antischizophrenic drugs
- Antipsychotic drug doses and neuroleptic/dopamine receptors
- Changes in dopamine-mediated behavior during one year's neuroleptic administration
- The broad-spectrum antimycobacterial activities of phenothiazines, in vitro: somewhere in all of this there may be patentable potentials (a review)
- Trifluoperazine hydrochloride (a review on the description, physical properties, synthesis, identification, stability, metabolism, and analysis)
- Derivative spectrophotometric, thin layer chromatographic-densitometric and high performance liquid chromatographic determination of trifluoperazine hydrochloride in presence of its hydrogen peroxide induced-degradation product
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