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Published TCIMAIL newest issue No.197
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CAS RN: 865-47-4 | Product Number: P1008
Potassium tert-Butoxide
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Purity: >97.0%(T)
Synonyms:
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 25G |
€18.00
|
18 | ≥100 |
|
| 100G |
€35.00
|
≥40 | ≥100 |
|
| 500G |
€125.00
|
25 | ≥100 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | P1008 |
| Purity / Analysis Method | >97.0%(T) |
| Molecular Formula / Molecular Weight | C__4H__9KO = 112.21 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Hygroscopic |
| CAS RN | 865-47-4 |
| Reaxys Registry Number | 3556712 |
| PubChem Substance ID | 87575121 |
| SDBS (AIST Spectral DB) | 18431 |
| MDL Number | MFCD00012162 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(Neutralization titration) | min. 97.0 % |
Properties (reference)
| Melting Point | 240 °C(dec.) |
| Solubility (soluble in) | Ether |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H314 : Causes severe skin burns and eye damage. H251 : Self-heating: may catch fire. |
| Precautionary Statements | P260 : Do not breathe dust. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. P303 + P361 + P353 : IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water. P304 + P340 + P310 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Immediately call a POISON CENTER/doctor. P305 + P351 + P338 + P310 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER/doctor. P407 : Maintain air gap between stacks or pallets. P413 : Store bulk masses greater than .? kg/ .? lbs at temperatures not exceeding .? °C/ .? °F. |
Related Laws:
| EC Number | 212-740-3 |
Transport Information:
| UN Number | UN3206 |
| Class | 4.2 / 8 |
| Packing Group | II |
| HS Number | 2905149000 |
Application
TCI Practical Example: Synthesis of Amide via the Meervein-Ponndolf-Verley Type Reaction Using tBuOK
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Used Chemicals
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Procedure
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To a solution of benzyl alcohol (540 mg, 5.0 mmol), benzonitrile (1.03 g, 10 mmol, 2.0 eq.) in 1,4-dioxane (10 mL) was added potassium tert-butoxide (1.12 g, 10.0 mmol, 2.0 eq.) at r.t. and the mixture was stirred at 130 °C for overnight. The solvent was removed under reduced pressure and the residue was purified by column chromatography (on silica gel, ethyl acetate:hexane = 0:1 - 1:2) several times, giving N-benzylbenzamide as a white solid (513 mg, 49% yield).
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Experimenter’s Comments
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The reaction mixture was monitored by UPLC.
The reaction was carried out using a pressure-resistant test tube.
Purification by column chromatography was performed several times.
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Analytical Data
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N-benzylbenzamide
1H NMR (270 MHz, DMSO-d6); δ 9.05 (brt, 1H, J = 5.4 Hz), 7.90 (dd, 1H, J = 7.3, 1.6 Hz), 7.56-7.44 (m, 3H), 7.36-7.32 (m, 4H), 7.25 (q, 1H, J = 7.3 Hz).
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Lead Reference
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- Direct Synthesis of Amides from Benzonitriles and Benzylic Alcohols via a KOt‑Bu-Mediated MPV-type Hydrogen Transfer Process
Application
Acetylation of Alcohols via Transesterification using Acetylating Reagents
References
- 1)Transesterification/Acylation of Secondary Alcohols Mediated by N-Heterocyclic Carbene Catalysts
- 2)Protection for the Hydroxyl Group, Including 1,2- and 1,3-Diols
- P. G. M. Wuts, in Greene’s Protective Groups in Organic Synthesis, 5th ed., ed. by P. G. M. Wuts, John Wiley & Sons, Inc., Hoboken, New Jersey, 2014, Chap. 2, 17.
Application
t-Butyldimethylsilylation of Alcohols using TBS Reagents
References
- Potassium tert-Butoxide-Catalyzed Dehydrogenative Si-O Coupling: Reactivity Pattern and Mechanism of an Underappreciated Alcohol Protection
- Protection for the Hydroxyl Group, Including 1,2- and 1,3-Diols
- P. G. M. Wuts, in Greene’s Protective Groups in Organic Synthesis, 5th ed., ed. by P. G. M. Wuts, John Wiley & Sons, Inc., Hoboken, New Jersey, 2014, Chap. 2, 17.
PubMed Literature
Articles/Brochures
Product Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
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Specifications
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Analytical Charts
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Other Documents
Related Products
Potassium tert-Butoxide (12% in Tetrahydrofuran, ca. 1mol/L)
| Product # | P1619 |
| CAS RN | 865-47-4 |
| Purity / Analysis Method: |