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Published TCIMAIL newest issue No.197
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CAS RN: 965-52-6 | Product Number: N1181
Nifuroxazide
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Purity: >98.0%(T)
Synonyms:
- Bacifurane
- 4-Hydroxy-N'-[(5-nitrofuran-2-yl)methylene]benzohydrazide
- (5-Nitro-2-furfurylidene)(4-hydroxybenzoyl)hydrazine
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 100MG |
€20.00
|
Contact Us | 26 |
|
| 500MG |
€63.00
|
3 | 23 |
|
| 5G |
€204.00
|
1 | 34 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | N1181 |
| Purity / Analysis Method | >98.0%(T) |
| Molecular Formula / Molecular Weight | C__1__2H__9N__3O__5 = 275.22 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Light Sensitive,Air Sensitive,Heat Sensitive |
| CAS RN | 965-52-6 |
| Reaxys Registry Number | 4264976 |
| PubChem Substance ID | 468592501 |
| Merck Index (14) | 6535 |
| MDL Number | MFCD00079482 |
Specifications
| Appearance | White to Yellow to Green powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 257 °C(dec.) |
GHS
Related Laws:
| EC Number | 213-522-0 |
| RTECS# | DH2528300 |
Transport Information:
| HS Number | 2941900000 |
Application
Quorum sensing research
Nifuroxazide showed inhibition of quorum sensing-regulated gene expression and related phenotypes in Pseudomonas aeruginosa in a dose-dependent manner. 1)
References
- 1) Computer-aided identification of recognized drugs as Pseudomonas aeruginosa quorum-sensing inhibitors
Application
Nifuroxazide: An Antibacterial Agent with STAT3 Inhibitory Activity
Nifuroxazide is a broad-spectrum antibacterial agent that has been used for the treatment of infectious diarrhea since 1960’s.1) In 2008, it was discovered that nifuroxazide is a potent inhibitor of the transcription factor STAT3.2) Since then, the potential of nifuroxazide as an anticancer agent has been investigated.3) (The product is for research purpose only.)
References
- 1) In vivo activity of nifurzide and nifuroxazide in intestinal bacteria in man and gnotobiotic mice
- 2) Nifuroxazide inhibits survival of multiple myeloma cells by directly inhibiting STAT3
- 3) Toward a repositioning of the antibacterial drug nifuroxazide for cancer treatment (a review)
- 4) Determination of nifuroxazide and drotaverine hydrochloride in pharmaceutical preparations by three independent analytical methods
Product Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
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Specifications
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