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CAS RN: 595-33-5 | Product Number: M1949
Megestrol Acetate
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Purity: >96.0%(HPLC)
Synonyms:
- Megestrol 17-Acetate
- 17α-Acethoxy-6-methyl-4,6-pregnadiene-3,20-dione
- 17α-Hydroxy-6-methyl-4,6-pregnadiene-3,20-dione 17-Acetate
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 1G |
69,00 €
|
Contact Us | 1 |
|
| 5G |
221,00 €
|
1 | 5 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | M1949 |
| Purity / Analysis Method | >96.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__4H__3__2O__4 = 384.52 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 595-33-5 |
| Reaxys Registry Number | 1917291 |
| PubChem Substance ID | 87560201 |
| Merck Index (14) | 5805 |
| MDL Number | MFCD00056470 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 96.0 area% |
| Melting point | 213.0 to 220.0 °C |
| Specific rotation [a]20/D | +9.0 to +13.0 deg(C=2, CHCl3) |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 218 °C |
| Specific Rotation | 11° (C=2,CHCl3) |
| Solubility (soluble in) | Chloroform |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H351 : Suspected of causing cancer. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up. |
Related Laws:
| EC Number | 209-864-5 |
| RTECS# | TU4075000 |
Transport Information:
| HS Number | 2937290000 |
Application
Megestrol Acetate: A Semi-Synthetic Progestational Agent
Megestrol acetate and medroxyprogesterone acetate [M1964], semi-synthetic progestational agents, are effective hormonal treatments for metastatic breast cancer in postmenopausal women. The antineoplastic effect may result from inhibition of pituitary gonadotropin production and resultant decrease in estrogen secretion. Recently, megestrol acetate is often used for the treatment of anorexia and cachexia. The precise mechanism is unknown at the present time. (The product is for research purpose only.)
References
- Comparison of the antiandrogenic/androgenic activities of flutamide, cyproterone acetate and megestrol acetate
- An overview of megestrol acetate for the treatment of advanced breast cancer (a review)
- Cytokine activity in cancer-related anorexia/cachexia: role of megestrol acetate and medroxyprogesterone acetate (a review)
- Treating malnutrition with megestrol acetate: literature review and review of our experience (a review)
- Trace analysis of androgens and progestogens in environmental waters by ultra-performance liquid chromatography-electrospray tandem mass spectrometry
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