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CAS RN: 602-85-7 | Product Number: L0413
Lysergol
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Purity: >98.0%(T)(HPLC)
Synonyms:
- (8β)-9,10-Didehydro-6-methylergoline-8-methanol
- [(6aR,9R)-7-Methyl-4,6,6a,7,8,9-hexahydroindolo[4,3-fg]quinolin-9-yl]methanol
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 5G |
€479.00
|
10 | 5 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | L0413 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__6H__1__8N__2O = 254.33 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| CAS RN | 602-85-7 |
| Reaxys Registry Number | 88476 |
| MDL Number | MFCD00010029 |
Specifications
| Appearance | White to Light yellow to Light orange powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Specific rotation | +50.0 to +55.0 deg (C=0.18, pyridine) |
| NMR | confirm to structure |
Properties (reference)
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H300 : Fatal if swallowed. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
Related Laws:
| EC Number | 210-024-5 |
| RTECS# | KE6330000 |
Transport Information:
| UN Number | UN1544 |
| Class | 6.1 |
| Packing Group | II |
| HS Number | 2939690000 |
Application
Lysergol: A Pharmacologically Important Ergot Alkaloid
Lysergol is belong to the ergot alkaloids that are pharmacologically important indole alkaloids which are secondary metabolites produced by filamentous fungi such as Claviceps purpurea.1) Lysergol has important pharmacological properties that engage various serotonin G protein-coupled receptors such as serotonin 5-HT1A and 5-HT2 receptors.2,3) In addition, lysergol is a natural bio-enhancer which promote and augment the bioavailability of the pharmaceutical agents.4-6) (The product is for research purpose only.)
References
- 1) Biochemistry of Ergot Alkaloids—Achievements and Challenges
- 2) Ergolines as selective 5-HT1 agonists
- 3) Cycloalkanecarboxylic Esters Derived from Lysergol, Dihydrolysergol-I, and Elymoclavine as Partial Agonists and Antagonists at Rat 5-HT2A Receptors: Pharmacological Evidence that the Indolo[4,3-fg]quinoline System of the Ergolines Is Responsible for High 5-HT2A Receptor Affinity
- 4) A mechanistic investigation of the bioavailability enhancing potential of lysergol, a novel bioenhancer, using curcumin
- 5) Simultaneous quantification of berberine and lysergol by HPLC-UV: evidence that lysergol enhances the oral bioavailability of berberine in rats
- 6) Natural bioenhancers: an overview
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