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CAS RN: 182431-12-5 | Product Number: L0298
Lomitapide
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Purity: >98.0%(HPLC)(qNMR)
Synonyms:
- N-(2,2,2-Trifluoroethyl)-9-[4-[4-[4'-(trifluoromethyl)-[1,1'-biphenyl]-2-ylcarboxamido]piperidin-1-yl]butyl]-9H-fluorene-9-carboxamide
- AEGR-733
- BMS-201038
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 25MG |
167,00 €
|
1 | 22 |
|
| 100MG |
448,00 €
|
1 | 33 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | L0298 |
| Purity / Analysis Method | >98.0%(HPLC)(qNMR) |
| Molecular Formula / Molecular Weight | C__3__9H__3__7F__6N__3O__2 = 693.73 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container | 100MG-Glass Bottle with Plastic Insert (View image), 25MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 182431-12-5 |
| Reaxys Registry Number | 13754976 |
| PubChem Substance ID | 354335361 |
| MDL Number | MFCD16620494 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(qNMR) | min. 98.0 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 142 °C |
GHS
Related Laws:
Transport Information:
| HS Number | 2933399990 |
Application
Lomitapide: A Microsomal Triglyceride Transfer Protein (MTP) Inhibitor
Lomitapide (AEGR-733 or BMS-201038) is a microsomal triglyceride transfer protein (MTP) inhibitor. MTP is a lipid transfer protein that resides in the endoplasmic reticulum of hepatocytes and intestinal epithelial cells, and is required for the assembly and secretion of apolipoprotein B (apo B)-containing lipoproteins by the liver and by the intestine. Lomitapide directly binds and inhibits MTP, thereby preventing the assembly of apolipoprotein B-containing lipoproteins in hepatocytes and intestinal epithelial cells. This inhibits the synthesis chylomicros of and very low-density lipoprotein (VLDL). The inhibition of the synthesis of VLDL leads to reduced levels of low-density lipoprotein cholesterol (LDC-C) in plasma. In addition, lomitapide mesylate [CAS: 202914-84-9] is used for clinical. (The product is for research purpose only.)
References
- Influence of triacylglycerol biosynthesis rate on the assembly of apoB-100-containing lipoproteins in Hep G2 cells.
- An MTP Inhibitor That Normalizes Atherogenic Lipoprotein Levels in WHHL Rabbits
- Lomitapide, a microsomal triglyceride transfer protein inhibitor for the treatment of hypercholesterolemia (a review)
- Microsomal transfer protein inhibition in humans (a review)
PubMed Literature
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