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CAS RN: 50264-69-2 | Product Number: L0283
Lonidamine
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Purity: >95.0%(T)(HPLC)
Synonyms:
- 1-(2,4-Dichlorobenzyl)-1H-indazole-3-carboxylic Acid
- Diclondazolic Acid
- Doridamina
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 250MG |
110,00 €
|
Contact Us | 7 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | L0283 |
| Purity / Analysis Method | >95.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__5H__1__0Cl__2N__2O__2 = 321.16 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive |
| CAS RN | 50264-69-2 |
| Reaxys Registry Number | 894483 |
| PubChem Substance ID | 468592141 |
| MDL Number | MFCD00866285 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Purity(Neutralization titration) | min. 95.0 % |
| Melting point | 208.0 to 212.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 210 °C |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
Related Laws:
| EC Number | 256-510-0 |
| RTECS# | NK7886000 |
Transport Information:
| HS Number | 2933998090 |
Application
Lonidamine: An Anticancer Agent Acting on Mitochondria
Lonidamine, a derivate of indazole-3-carboxylic acid, was initially developed as an anti-spermatogenic agent. It was later reported to have anticancer activity with a peculiar mechanism of action. Lonidamine has no function on cellular nucleic acids or protein synthesis, whereas acts on mitochondria to induce apoptosis. Thus, lonidamine exerts a powerful inhibitory effect on oxygen consumption, aerobic glycolysis and lactate transport and accumulation of neoplastic cells. Although the clinical development of lonidamine have been discontinued, it has recently attracted attention as a combination agent with other antitumor agents. (The product is for research purpose only.)
References
- Lonidamine triggers apoptosis via a direct, Bcl-2-inhibited effect on the mitochondrial permeability transition pore
- Mechanism of antineoplastic activity of lonidamine
- Reviving lonidamine and 6-diazo-5-oxo-L-norleucine to be used in combination for metabolic cancer therapy
Product Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
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Specifications
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